VERAPAMIL HYDROCHLORIDE tablet film coated

Država: Združene države Amerike

Jezik: angleščina

Source: NLM (National Library of Medicine)

Aktivna sestavina:

VERAPAMIL HYDROCHLORIDE (UNII: V3888OEY5R) (VERAPAMIL - UNII:CJ0O37KU29)

Dostopno od:

Clinical Solutions Wholesale

INN (mednarodno ime):

VERAPAMIL HYDROCHLORIDE

Sestava:

VERAPAMIL HYDROCHLORIDE 80 mg

Tip zastaranja:

PRESCRIPTION DRUG

Status dovoljenje:

Abbreviated New Drug Application

Lastnosti izdelka

VERAPAMIL HYDROCHLORIDE- VERAPAMIL HYDROCHLORIDE TABLET, FILM COATED
CLINICAL SOLUTIONS WHOLESALE
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VERAPAMIL HYDROCHLORIDE TABLETS USP
REVISED: JANUARY 2014
RX ONLY
DESCRIPTION
Verapamil hydrochloride is a calcium ion influx inhibitor
(slow-channel blocker or calcium ion
antagonist) available for oral administration in film-coated tablets
containing 40 mg, 80 mg, or 120 mg
of verapamil hydrochloride.
The structural formula of verapamil hydrochloride is:
Benzeneacetonitrile,
α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-
methylethyl) hydrochloride.
Verapamil hydrochloride is an almost white, crystalline powder,
practically free of odor, with a bitter
taste. It is soluble in water, chloroform, and methanol. Verapamil
hydrochloride is not chemically
related to other cardioactive drugs.
Inactive ingredients include anhydrous lactose, corn starch,
hypromellose 2910, magnesium stearate,
microcrystalline cellulose, polacrilin potassium, and polyethylene
glycol 400. In addition the following
coloring agents are used: FD&C Yellow No. 6 Aluminum Lake,
hydroxypropyl cellulose and titanium
dioxide (40 mg light peach); hydroxypropyl cellulose and titanium
dioxide (80 mg white and 120 mg
white).
CLINICAL PHARMACOLOGY
Verapamil hydrochloride is a calcium ion influx inhibitor
(slow-channel blocker or calcium ion
antagonist) that exerts its pharmacologic effects by modulating the
influx of ionic calcium across the
cell membrane of the arterial smooth muscle as well as in conductile
and contractile myocardial cells.
MECHANISM OF ACTION
ANGINA: The precise mechanism of action of verapamil hydrochloride as
an antianginal agent remains to
be fully determined, but includes the following two mechanisms:
1 _. Relaxation and prevention of coronary artery spasm:_ Verapamil
dilates the main coronary arteries and
coronary arterioles, both in normal and ischemic regions, and is a
potent inhibitor of coronary artery
spasm, whether spontaneous or ergonovine-induced. This property
increases myocardial ox