TRIAMTERENE HYDROCHLOROTHIAZIDE and tablet

Država: Združene države Amerike

Jezik: angleščina

Source: NLM (National Library of Medicine)

Aktivna sestavina:

TRIAMTERENE (UNII: WS821Z52LQ) (TRIAMTERENE - UNII:WS821Z52LQ)

Dostopno od:

Lake Erie Medical DBA Quality Care Products LLC

INN (mednarodno ime):

TRIAMTERENE

Sestava:

TRIAMTERENE 37.5 mg

Tip zastaranja:

PRESCRIPTION DRUG

Status dovoljenje:

Abbreviated New Drug Application

Lastnosti izdelka

TRIAMTERENE HYDROCHLOROTHIAZIDE- TRIAMTERENE AND HYDROCHLOROTHIAZIDE
TABLET
LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC
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TRIAMTERENE AND HYDROCHLOROTHIAZIDE TABLETS, USP
DESCRIPTION
Triamterene and hydrochlorothiazide tablets combine triamterene, a
potassium-conserving diuretic with
the natriuretic agent hydrochlorothiazide. Each tablet for oral
administration contains 37.5 mg
triamterene and 25 mg hydrochlorothiazide or 75 mg triamterene and 50
mg hydrochlorothiazide.
Inactive ingredients include croscarmellose sodium, D & C Yellow #10
Aluminum Lake,
hydroxypropyl methylcellulose, magnesium stearate, microcrystalline
cellulose, polysorbate 80, and
sodium bicarbonate. The 37.5 MG/25 MG tablet also contains FD & C Blue
#1 Aluminum Lake.
Triamterene is 2,4,7-triamino-6-phenylpteridine. Triamterene is
practically insoluble in water, benzene,
chloroform, ether and dilute alkali hydroxides. It is soluble in
formic acid and sparingly soluble in
methoxyethanol. Triamterene is very slightly soluble in acetic acid,
alcohol and dilute mineral acids. Its
molecular weight is 253.27. Its structural formula is:
Hydrochlorothiazide is 6-chloro-3,4-dihydro-2_H_-1,2,4,
benzothiadiazine-7-sulfonamide 1, 1-dioxide.
Hydrochlorothiazide is slightly soluble in water and freely soluble in
sodium hydroxide solution, n-
butylamine and dimethylformamide. It is sparingly soluble in methanol
and insoluble in ether,
chloroform and dilute mineral acids. Its molecular weight is 297.73.
Its structural formula is:
CLINICAL PHARMACOLOGY
Triamterene and hydrochlorothiazide is a diuretic, antihypertensive
drug product, principally due to its
hydrochlorothiazide component; the triamterene component reduces the
excessive potassium loss which
may occur with hydrochlorothiazide use.
TRIAMTERENE
Triamterene is a potassium conserving (antikaliuretic) diuretic with
relatively weak natriuretic
properties. It exerts its diuretic effect on the distal renal tubule
to inhibit the reabsorption of sodium in
exchange for potassium and hydrogen. With