Rifadin

Država: Avstralija

Jezik: angleščina

Source: Department of Health (Therapeutic Goods Administration)

Aktivna sestavina:

Rifampicin

Dostopno od:

Sanofi-Aventis Australia Pty Ltd

Razred:

Medicine Registered

Lastnosti izdelka

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PRODUCT INFORMATION 
RIFADIN
®

NAME OF THE MEDICINE 
NON-PROPRIETARY NAME 
rifampicin  
CHEMICAL STRUCTURE 

C
43
H
58
N
4
O
12

DESCRIPTION

Rifampicin is a semisynthetic antibiotic derivative of
rifamycin B. Specifically, rifampicin is the hydrazone, 
3-(4-methylpiperazinyliminomethyl) rifamycin SV. It
is only slightly soluble in water and is rather unstable 
to light and moisture. 
Excipients present in the capsules are maize starch, magnesium
stearate, titanium dioxide, erythrosine, 
indigo carmine and gelatin. 
Excipients present in the tablets are sodium lauryl
sulfate, microcrystalline cellulose, lactose, calcium 
stearate, carmellose sodium, maize starch, magnesium
stearate, acacia, PVP, erythrosine, titanium dioxide, 
sucrose, talc, magnesium carbonate, kaolin, colloidal
silica and gelatin. 

Excipients present in the injection are sodium formaldehyde sulfoxylate
and sodium hydroxide, the diluent 
is water for injections. 
Excipients present in the syrup are agar, sucrose, methyl
hydroxybenzoate, propyl hydroxybenzoate, 
potassium sorbate, saccharin, sodium metabisulfite, polysorbate 80,
raspberry essence, diethanolamine 
and purified water. 
PHARMACOLOGY 
Rifampicin is particularly active against rapidly
growing extracellular organisms but it also has 
bactericidal activity intracellularly and against slow and
intermittently growing _Mycobacterium _
_tuberculosis.  _Rifampicin inhibits DNA dependent
RNA polymerase activity in susceptible cells. 
Specifically, it interacts with bacterial RNA polymerase, but does
not inhibit the mammalian enzyme. 
Cross resistance to rifampicin has only been shown with other
rifamycins. 
PHARMACOKINETICS 
Rifampicin is readily absorbed from the stomach and
the