PRAZOSIN- prazosin hydrochloride capsule

Država: Združene države Amerike

Jezik: angleščina

Source: NLM (National Library of Medicine)

Aktivna sestavina:

PRAZOSIN HYDROCHLORIDE (UNII: X0Z7454B90) (PRAZOSIN - UNII:XM03YJ541D)

Dostopno od:

A-S Medication Solutions

Pot uporabe:

ORAL

Tip zastaranja:

PRESCRIPTION DRUG

Terapevtske indikacije:

Prazosin hydrochloride capsules are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including this drug. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC). Numerous antihypertensive drugs, from a variety of pharmacologic classes and

Povzetek izdelek:

Product: 50090-3072 NDC: 50090-3072-0 44 CAPSULE in a BOTTLE

Status dovoljenje:

New Drug Application Authorized Generic

Lastnosti izdelka

PRAZOSIN- PRAZOSIN HYDROCHLORIDE CAPSULE
A-S MEDICATION SOLUTIONS
----------
PRAZOSIN HYDROCHLORIDE
CAPS ULES
_FOR ORAL USE_
DESCRIPTION
Prazosin hydrochloride, a quinazoline derivative, is the first of a
new chemical class of
antihypertensives. It is the hydrochloride salt of
1-(4-amino-6,7-dimethoxy- 2-quinazolinyl)-4-(2-
furoyl) piperazine and its structural formula is:
MOLECULAR FORMULA C H N O ·HCL
It is a white, crystalline substance, slightly soluble in water and
isotonic saline, and has a molecular
weight of 419.87. Each 1 mg capsule of prazosin hydrochloride for oral
use contains drug equivalent
to 1 mg free base.
Inert ingredients in the formulations are: hard gelatin capsules
(which may contain Blue 1, Red 3, Red
28, Red 40, and other inert ingredients); magnesium stearate; sodium
lauryl sulfate; starch; sucrose.
CLINICAL PHARMACOLOGY
The exact mechanism of the hypotensive action of prazosin is unknown.
Prazosin causes a decrease in
total peripheral resistance and was originally thought to have a
direct relaxant action on vascular smooth
muscle. Recent animal studies, however, have suggested that the
vasodilator effect of prazosin is also
related to blockade of postsynaptic alpha-adrenoceptors. The results
of dog forelimb experiments
demonstrate that the peripheral vasodilator effect of prazosin is
confined mainly to the level of the
resistance vessels (arterioles). Unlike conventional alpha-blockers,
the antihypertensive action of
prazosin is usually not accompanied by a reflex tachycardia. Tolerance
has not been observed to
develop in long term therapy.
Hemodynamic studies have been carried out in man following acute
single dose administration and
during the course of long term maintenance therapy. The results
confirm that the therapeutic effect is a
fall in blood pressure unaccompanied by a clinically significant
change in cardiac output, heart rate,
renal blood flow and glomerular filtration rate. There is no
measurable negative chronotropic effect.
In clinical studies to date, prazosin hydrochlor