OXYBUTYNIN CHLORIDE tablet

Država: Združene države Amerike

Jezik: angleščina

Source: NLM (National Library of Medicine)

Aktivna sestavina:

OXYBUTYNIN CHLORIDE (UNII: L9F3D9RENQ) (OXYBUTYNIN - UNII:K9P6MC7092)

Dostopno od:

St Marys Medical Park Pharmacy

INN (mednarodno ime):

OXYBUTYNIN CHLORIDE

Sestava:

OXYBUTYNIN CHLORIDE 5 mg

Tip zastaranja:

PRESCRIPTION DRUG

Status dovoljenje:

Abbreviated New Drug Application

Lastnosti izdelka

OXYBUTYNIN CHLORIDE - OXYBUTYNIN CHLORIDE TABLET
ST MARYS MEDICAL PARK PHARMACY
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OXYBUTYNIN CHLORIDE TABLETS USP
Rev. C 4/2012
DESCRIPTION
Oxybutynin chloride tablets USP are very pale blue, round, biconvex,
scored, debossed tablets
containing 5 mg of oxybutynin chloride, USP. Chemically, oxybutynin
chloride, USP is d,l (racemic) 4-
diethylamino-2-butynyl phenylcyclohexylglycolate hydrochloride. The
structural formula appears
below:
C
H NO •HCL M.W. 393.9
Oxybutynin chloride, USP is a white crystalline solid. It is readily
soluble in water and acids, but
relatively insoluble in alkalis.
Oxybutynin chloride tablets USP also contain calcium stearate,
microcrystalline cellulose, anhydrous
lactose, sodium starch glycolate and FD&C Blue #1 Aluminum Lake.
Oxybutynin chloride tablets USP are for oral administration.
Meets USP Dissolution Test 2.
Therapeutic Category: Antispasmodic, anticholinergic.
CLINICAL PHARMACOLOGY
Oxybutynin chloride exerts a direct antispasmodic effect on smooth
muscle and inhibits the muscarinic
action of acetylcholine on smooth muscle. Oxybutynin chloride exhibits
only one fifth of the
anticholinergic activity of atropine on the rabbit detrusor muscle,
but four to ten times the antispasmodic
activity. No blocking effects occur at skeletal neuromuscular
junctions or autonomic ganglia
(antinicotinic effects).
Oxybutynin chloride relaxes bladder smooth muscle. In patients with
conditions characterized by
involuntary bladder contractions, cystometric studies have
demonstrated that oxybutynin chloride
increases bladder (vesical) capacity, diminishes the frequency of
uninhibited contractions of the
detrusor muscle, and delays the initial desire to void. Oxybutynin
chloride thus decreases urgency and
the frequency of both incontinent episodes and voluntary urination.
Antimuscarinic activity resides predominately in the R-isomer. A
metabolite, desethyloxybutynin, has
pharmacological activity similar to that of oxybutynin in _invitro_
studies.
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PHARMACOKINETICS
Absorption
Following or