Država: Malezija
Jezik: angleščina
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
AFOXOLANER
Rhone Ma Malaysia Sdn Bhd
AFOXOLANER
3tablet Tablets; 6tablet Tablets
Boehringer Ingelheim Animal Health do Brasil Ltda
Not Available Preberite celoten dokument
11 mg chewable tablets for dogs 2–4 kg 28 mg chewable tablets for dogs >4–10 kg 68 mg chewable tablets for dogs >10–25 kg 136 mg chewable tablets for dogs >25–50 kg MANUFACTURED BY: Boehringer Ingelheim Animal Health do Brasil Ltda, Avenida Doutor Roberto Moreira, no. 5005, Reference Point: Fazenda Sao Francisco, Recanto dos Passaros, CEP 13148-914 Paulinia/SP-Brazil. MANUFACTURER RESPONSIBLE FOR BATCH RELEASE: B oehringer Ingelheim Animal Health France, 4 Chemin du Calquet - 31000 Toulouse - France. REGISTRATION HOLDER AND REPACKER: RHONE MA MALAYSIA SDN BHD (200001023279) Lot 18A & 18B, Jalan 241, Seksyen 51A 46100 Petaling Jaya, Selangor, Malaysia Tel: 03-7873 7355 Fax: 03-2770 0119 Email: customercareline@rhonema.com STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENT(S) Each chewable tablet contains: NexGard chewable tablets for dogs 2–4 kg 11.3 chewable tablets for dogs >4–10 kg 28.3 chewable tablets for dogs >10–25 kg 68.0 chewable tablets for dogs >25–50 kg 136.0 Afoxolaner (mg) Bodyweight of dog (kg) Strength and number of chewable tablets to be administered NexGard 1 11 mg NexGard 28 mg NexGard 68 mg NexGard 136 mg 1 1 1 2 - 4 >4–10 >10–25 >25–50 Mottled red to reddish brown, circular shaped (tablets for dogs 2-4 kg), or rectangular shaped (tablet for dogs >4-10 kg, tablets for dogs >10-25 kg and tablets for dogs > 25-50 kg). PHARMACODYNAMICS Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family. Afoxolaner acts at ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects or acarines. The selective toxicity of afoxolaner between insect/acarines and mammals may be inferred by the differential sensitivity of the insect/acarines’ GABA receptors versus mammalian receptors. Afoxolaner is active against adult fleas as well as Preberite celoten dokument