NexGard 136mg chewable tablets for dogs > 25-50kg
Država: Malezija
Jezik: angleščina
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Navodilo za uporabo
(PIL)
10-10-2017
Lastnosti izdelka
(SPC)
02-08-2023
Aktivna sestavina:
AFOXOLANER
Dostopno od:
Rhone Ma Malaysia Sdn Bhd
INN (mednarodno ime):
AFOXOLANER
Enote v paketu:
3tablet Tablets; 6tablet Tablets
Izdeluje:
Boehringer Ingelheim Animal Health do Brasil Ltda
Navodilo za uporabo
Not Available
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Lastnosti izdelka
11 mg chewable tablets for dogs 2–4 kg
28 mg chewable tablets for dogs >4–10 kg
68 mg chewable tablets for dogs >10–25 kg
136 mg chewable tablets for dogs >25–50 kg
MANUFACTURED BY:
Boehringer Ingelheim Animal Health do Brasil Ltda,
Avenida Doutor Roberto Moreira, no. 5005, Reference Point: Fazenda
Sao Francisco, Recanto dos Passaros, CEP 13148-914 Paulinia/SP-Brazil.
MANUFACTURER RESPONSIBLE FOR BATCH RELEASE:
B oehringer Ingelheim Animal Health France,
4 Chemin du Calquet - 31000 Toulouse - France.
REGISTRATION HOLDER AND REPACKER:
RHONE MA MALAYSIA SDN BHD
(200001023279)
Lot 18A & 18B, Jalan 241, Seksyen 51A
46100 Petaling Jaya, Selangor, Malaysia
Tel: 03-7873 7355 Fax: 03-2770 0119
Email: customercareline@rhonema.com
STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENT(S)
Each chewable tablet contains:
NexGard
chewable tablets for dogs 2–4 kg
11.3
chewable tablets for dogs >4–10 kg
28.3
chewable tablets for dogs >10–25 kg
68.0
chewable tablets for dogs >25–50 kg
136.0
Afoxolaner (mg)
Bodyweight
of dog (kg)
Strength and number of chewable tablets
to be administered
NexGard
1 11 mg
NexGard 28 mg
NexGard 68 mg
NexGard 136 mg
1
1
1
2 - 4
>4–10
>10–25
>25–50
Mottled red to reddish brown, circular shaped (tablets for dogs 2-4
kg), or rectangular shaped (tablet for dogs >4-10 kg,
tablets for dogs >10-25 kg and tablets for dogs > 25-50 kg).
PHARMACODYNAMICS
Afoxolaner is an insecticide and acaricide belonging to the
isoxazoline family. Afoxolaner acts at ligand-gated chloride
channels, in particular those gated by the neurotransmitter
gamma-aminobutyric acid (GABA), thereby blocking pre- and
post-synaptic transfer of chloride ions across cell membranes. This
results in uncontrolled activity of the central nervous
system and death of insects or acarines. The selective toxicity of
afoxolaner between insect/acarines and mammals may be
inferred by the differential sensitivity of the insect/acarines’
GABA receptors versus mammalian receptors.
Afoxolaner is active against adult fleas as well as
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