Minipress

Država: Avstralija

Jezik: angleščina

Source: Department of Health (Therapeutic Goods Administration)

Aktivna sestavina:

Prazosin hydrochloride

Dostopno od:

Pfizer Australia Pty Ltd

Razred:

Medicine Listed (Export Only)

Navodilo za uporabo

MINIPRESS
®
 TABLETS

_Prazosin (praz-o-sin)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Minipress. It does
not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Minipress
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
READ THIS LEAFLET CAREFULLY BEFORE
STARTING MINIPRESS. KEEP IT WITH
YOUR MEDICINE. YOU MAY NEED TO
READ IT AGAIN.
WHAT MINIPRESS IS
USED FOR
Minipress is used to treat:
•
high blood pressure, also called
hypertension
•
benign prostatic hyperplasia or
BPH ('prostrate trouble') in men
waiting for prostate surgery
•
Raynaud's disease, where the
fingers become white and painful
when cold
•
certain types of heart failure.
When used to treat high blood
pressure or heart failure, Minipress is
often used in combination with other
medicines.
Minipress belongs to a family of
medicines called alpha blockers.
These medicines work by relaxing
muscles in the walls of blood vessels
and reducing the resistance to blood
flow. They also relieve prostate
problems by relaxing muscles in the
prostate gland and increasing the
flow of urine.
Your doctor may have prescribed
Minipress for another reason.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY MINIPRESS HAS
BEEN PRESCRIBED FOR YOU.
This medicine is only available with
a doctor's prescription.
BEFORE YOU TAKE
MINIPRESS
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE MINIPRESS IF YOU HAVE
AN ALLERGY TO:
•
prazosin (the active ingredient in
Minipress) or any of the
ingredients listed at the end of
this leaflet
•
related medicines (e.g. Pratsiol,
Miniprosin, Prasig, Mipraz,
Carduran, Hytrin or other
quinazolines).
ASK YOUR PHARMACIST IF YOU ARE NOT
SURE IF YOU ARE TAKING ONE OF THESE
MEDICINES.
Symptoms of an allergic reaction to
these medicines may incl

Lastnosti izdelka

Version: pfpminit10212

Supersedes:  pfpminit10905 

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PRODUCT INFORMATION 
MINIPRESS
Ò 
(PRAZOSIN HYDROCHLORIDE)  
NAME OF THE MEDICINE  
MNIPRESS (prazosin hydrochloride), a quinazoline derivative,
is the first antihypertensive of its 
chemical class. It is the hydrochloride
salt of 1-(4-amino-6,7-dimethoxyquinazolin-2-yl)-4-(furan-2-
ylcarbonyl) piperazine and its structural formula is: 
Molecular weight is 419.87 and the CAS number 19237-84-4. 
DESCRIPTION  
Prazosin hydrochloride is a white or almost white powder,
very slightly soluble in water, 
slightly soluble in alcohol and in methanol,
practically insoluble in acetone.  
MINIPRESS tablets contain prazosin hydrochloride equivalent to
the stated content of prazosin 
base and the following inactive ingredients calcium hydrogen
phosphate anhydrous, starch  - 
maize,
microcrystalline cellulose, magnesium stearate and sodium lauryl sulfate. The 1 mg 
tablet also contains sunset yellow FCF CI 15985 (aluminium lake). 
PHARMACOLOGY 
PHARMACODYNAMICS 
Prazosin causes a decrease
in total peripheral resistance. Animal studies suggest that
the 
vasodilator effect of prazosin is related to
blockade of post-synaptic alpha-adrenoreceptors. 
The results of dog forelimb experiments demonstrate that
the peripheral vasodilator effect is 
confined mainly to the level of the
resistance vessels (arterioles). Unlike conventional alpha-
blockers the antihypertensive action of prazosin
is usually not accompanied by reflex 
tachycardia. 
Haemodynamic studies have been carried out in
hypertensive patients following acute single 
dose administration and during
the course of long-term maintenance therapy. The results 
confirm that the usual therapeutic effect is a fall in blood
pressure unaccompanied by a 
clinically significant change in cardiac output, heart rate,
renal bloo