Država: Kanada
Jezik: angleščina
Source: Health Canada
GLYCOPYRROLATE
MONT-PHARMA INC
A03AB02
GLYCOPYRRONIUM
4MG
SOLUTION
GLYCOPYRROLATE 4MG
INTRAMUSCULAR
1X20 ML
Ethical
ANTIMUSCARINICS ANTISPASMODICS
Active ingredient group (AIG) number: 0102396002; AHFS:
APPROVED
2018-07-23
PRODUCT MONOGRAPH GLYCOPYRROLATE INJECTION MULTIDOSE 0.2 MG / ML HOUSE STANDARD (Medicinal Ingredient: Each mL contains: Glycopyrrolate 0.2 mg.) (CONTAINS BENZYL ALCOHOL) ANTICHOLINERGIC FOR INTRAMUSCULAR OR INTRAVENOUS ADMINISTRATION STERILE SOLUTION FOR INJECTION Mont-Pharma Inc. 2379 Rue Guénette Saint Laurent, Québec H4R 2E9 Control # 216942 Date of preparation: July 23, 2018 - 2 - GLYCOPYRROLATE INJECTION MULTIDOSE 0.2 MG / ML HOUSE STANDARD THERAPEUTIC CLASSIFICATION Anticholinergic ACTION AND CLINICAL PHARMACOLOGY Glycopyrrolate, like other anticholinergic (antimuscarinic) agents, competitively antagonizes the action of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. Glycopyrrolate antagonizes muscarinic symptoms (e.g., bronchorrhea, bronchospasm, bradycardia and intestinal hypermotility) induced by cholinergic drugs such as anticholinesterases. As a premedicant, Glycopyrrolate Injection reduces excessive pharyngeal, tracheal and bronchial secretions and, during anesthesia, it appears to protect the heart against excessive vagal stimulation. The polar ammonium moiety of glycopyrrolate limits its passage across lipid membranes such as the blood-brain barrier, in contrast to the belladonna alkaloids (such as atropine), which are nonpolar tertiary amines. Consequently, Glycopyrrolate Injection does not cause the central nervous system effects seen with the belladonna alkaloids. The onset of action following intramuscular injection of injectable glycopyrrolate is 20 to 40 minutes. Peak effects occur approximately 30 to 45 minutes after administration and the duration of action ranges from 4 to 6 hours. With intravenous injection, the onset of action is generally evident within one minute; the duration of action varies, as does that of all other anticholinergics. Following intravenous glycopyrrolate, the vagal blocking effects persist for 2 to 3 hours and the antisialagogue effects persist up to 7 Preberite celoten dokument