FUROSEMIDE INJECTION USP SOLUTION

Država: Kanada

Jezik: angleščina

Source: Health Canada

Aktivna sestavina:

FUROSEMIDE

Dostopno od:

HIKMA CANADA LIMITED

Koda artikla:

C03CA01

INN (mednarodno ime):

FUROSEMIDE

Odmerek:

20MG

Farmacevtska oblika:

SOLUTION

Sestava:

FUROSEMIDE 20MG

Pot uporabe:

INTRAMUSCULAR

Enote v paketu:

15G/50G

Tip zastaranja:

Prescription

Terapevtsko območje:

LOOP DIURETICS

Povzetek izdelek:

Active ingredient group (AIG) number: 0101944003; AHFS:

Status dovoljenje:

APPROVED

Datum dovoljenje:

2021-09-08

Lastnosti izdelka

Page 1 of 17
PRODUCT MONOGRAPH
PR
FUROSEMIDE INJECTION USP
(10 mg/mL) Sterile
Diuretic
Hikma Canada Limited
5995 Avebury Road, Suite 804
Mississauga, Ontario
L5R 3P9
Control # 262710
Date of Preparation:
April 26, 2022
Page 2 of 17
PR
FUROSEMIDE INJECTION USP
(10 MG/ML)
THERAPEUTIC CLASSIFICATION
Diuretic
CLINICAL PHARMACOLOGY
Furosemide has no significant pharmacological effects other than on
the renal function.
RENAL PHARMACOLOGY
In dogs, furosemide demonstrated diuretic properties. Diuresis and
sodium extraction were induced
by doses of 0.125 mg/kg administered intravenously or 0.5 mg/kg
administered orally.
Maximum water and sodium excretion is obtained by oral and intravenous
doses of 12.5 and
25 mg/kg respectively. Increased potassium excretion can only be
demonstrated with doses
exceeding 1 mg/kg. The onset of action is rapid after intravenous and
oral administration and the
duration of activity is approximately 2 and 4 hours respectively.
Furosemide produces an immediate diuresis after intravenous
administration and is effective
unilaterally after injection into a renal artery. Its action,
therefore, is directly on the kidney. The
diuretic response is prompt and relatively brief. At the peak of
diuretic response 30-40% of the
filtered sodium load may be excreted, along with some potassium and
with chloride as the major
anion. Furosemide augments the potassium output as a result of
increased distal potassium
secretion.
Its diuretic action is independent of changes in acid-base balance.
Under conditions of acidosis or alkalosis the diuretic produces a
chloruresis without augmentation of
bicarbonate excretion. It does not inhibit carbonic anhydrase.
On the basis of changes in free-water production furosemide inhibits
sodium reabsorption in the
ascending limb of Henle's loop. However, proximal sites of action are
also involved, as determined
by micropuncture. Partial distal inhibition of sodium reabsorption is
also possible. It also decreases
the urinary excretion of uric acid and prolonged administration may