Država: Južnoafriška republika
Jezik: angleščina
Source: South African Health Products Regulatory Authority (SAHPRA)
Smith_kb
INDICATIONS [/za_1135.html#1] [/za_1135.html#1] [/za_1135.html#1] CONTRA-INDICATIONS [/za_1135.html#1] [/za_1135.html#1] DOSAGE [/za_1135.html#1] [/za_1135.html#1] SIDE-EFFECTS [/za_1135.html#1] [/za_1135.html#1] [/za_1135.html#1] PREGNANCY [/za_1135.html#1] [/za_1135.html#1] OVERDOSE [/za_1135.html#1] IDENTIFICATION [/za_1135.html#1] [/za_1135.html#1] PATIENT INFORMATION ‘FURADANTIN’TABLETS 50 MG ‘FURADANTIN’TABLETS 100 MG ‘FURADANTIN’SUSPENSION 25 MG/ ML SCHEDULING STATUS: S4 PROPRIETARY NAMES (and dosage form): ‘FURADANTIN’TABLETS 50 MG ‘FURADANTIN’TABLETS 100 MG ‘FURADANTIN’SUSPENSION 25 MG/ ML COMPOSITION: Each ‘Furadantin’Tablet contains 50 mg or 100 mg NITROFURANTOIN . The chemical name is 1[(5-nitrofur- furylidene)amino]hydantoin. Each 5 mL of suspension curtains 25 mg nitrofurantoin. The suspension also contains methyl p-hydroxy benzoate 0,10% m/v and propyl P-hydroxybenzoate 0,02% m/v as preservatives. PHARMACOLOGICAL CLASSIFICATION: A.18.5 Urinary tract antiseptics. PHARMACOLOGICAL ACTION: Clinical Pharmacology: Orally administered ‘Furadantin’is readily absorbed and rapidly excreted in urine. During therapeutic drug dosage, only low blood concentrations are usually present. It is highly soluble in urine, to which it may impart a brown colour. Following a therapeutic dose regimen (100 mg four times a day for 7 days) average urinary drug recoveries (0 - 24 hours) on day 1 and day 7 were 42,7% and 43,6% respectively, for ‘Furadantin’. Microbiology: ‘Furadantin’is an antibacterial agent for specific urinary tract infections. It is bacteriostatic in low concentrations (10 µg/mL to 5 µg/mL) and in vitro is considered to be bactericidal in higher concentrations. Its presumed mode of action is based upon its interference with seve Preberite celoten dokument