EPINEPHRINE injection

Država: Združene države Amerike

Jezik: angleščina

Source: NLM (National Library of Medicine)

Aktivna sestavina:

EPINEPHRINE (UNII: YKH834O4BH) (EPINEPHRINE - UNII:YKH834O4BH)

Dostopno od:

BPI LABS LLC

Pot uporabe:

INTRAVENOUS

Tip zastaranja:

PRESCRIPTION DRUG

Terapevtske indikacije:

EPINEPHRINE Epinephrine’s cardiac effects may be of use in the treatment and prophylaxis of cardiac arrest due to various causes in the absence of ventricular fibrillation and attacks of transitory atrioventricular (AV) heart block with syncopal seizures (Stokes-Adams syndrome), but it is not used in cardiac failure or in hemorrhagic, traumatic or in cardiogenic shock. Epinephrine may be used to stimulate the heart in syncope due to complete heart block or carotid sinus hypersensitivity. Epinephrine is also used for resuscitation in cardiac arrest following anesthetic accidents. In cardiopulmonary resuscitation, intracardiac puncture and intramyocardial injection of epinephrine may be effective when external cardiac compression and attempts to restore the circulation by electrical defibillation or use of a pacemaker fail. Epinephrine is seldom used as a vasopressor except in the treatment of anaphylactic shock and under certain conditions in insulin shock. Epinephrine should not be used in the presence of car

Povzetek izdelek:

EPINEPHRINE INJECTION, 1 mg/10 mL (0.1 mg/mL) is available as NDC 54288-155-01               One Single-Dose Prefilled Syinge per carton. NDC 54288-155-10               10 Single-Dose Prefilled Syinges per carton. Discard unused portion. Protect the solution from light, extreme heat and freezing. Store at room temperature, between 20° to 25°C (68° to 77°F). NOTE: Do not use the solution if it is colored or cloudy, or if it contains particulate matter. Manufactured By: BPI Labs, LLC 12393 Belcher Road S, Suite 450, Largo, FL 33773 USA LI45I     R-2303

Status dovoljenje:

unapproved drug other

Lastnosti izdelka

EPINEPHRINE- EPINEPHRINE INJECTION
BPI LABS LLC
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this_
_labeling has not been approved by FDA. For further information about
unapproved_
_drugs, click here._
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EPINEPHRINE INJECTION, USP
AVAILABLE AS:
EPINEPHRINE INJECTION, USP 0.1 MG/ML
FOR INTRACARDIAC OR INTRAVENOUS USE ONLY
Epinephrine Injection, USP is a clear, colorless, sterile solution
containing 0.1 mg/mL
epinephrine, packaged as a 10 mL solution in a Single-dose clear glass
syringe. Each mL
of Epinephrine Injection, USP solution contains 0.1 mg epinephrine,
8.6 mg sodium
chloride, 0.5 mg sodium metabisulfite, hydrochloric acid for pH
adjustment and water
for injection. The pH range is 2.2-5.0.
Epinephrine is a sympathomimetic catecholamine. The chemical name of
epinephrine is:
1,2- Benzenediol, 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-, or
(-)-3,4-Dihydroxy-α-[2-
(methylamino)ethyl]benzyl alcohol. The chemical structure of
epinephrine is:
The molecular weight of epinephrine is 183.2.
Epinephrine solution deteriorates rapidly on exposure to air or light,
turning pink from
oxidation to adrenochrome and brown from the formation of melanin.
CLINICAL PHARMACOLOGY
The actions of epinephrine resemble the effects of stimulation of
adrenergic nerves. To a
variable degree, it acts on both alpha and beta receptor sites of
sympathetic effector
cells. Its most prominent actions are on the beta receptors of the
heart, vascular and
other smooth muscle. When given by rapid I.V. injection it produces a
rapid rise in blood
pressure, mainly systolic, direct stimulation of cardiac muscle which
increases the
strength of ventricular contraction, increases the heart rate, and
constricts the
arterioles in the skin, mucosa and splanchnic areas of circulation.
Epinephrine relaxes the smooth muscle of the bronchi and iris and is a
physiologic
antagonist of histamine.
The drug also produces an increase in blood sugar and glycogenolysis
in the liver.
BLOOD PRESSURE:When given by slow I.V. injecti