EPINEPHRINE - epinephrine injection

Država: Združene države Amerike

Jezik: angleščina

Source: NLM (National Library of Medicine)

Aktivna sestavina:

Epinephrine (UNII: YKH834O4BH) (Epinephrine - UNII:YKH834O4BH)

Dostopno od:

International Medication Systems, Limited

Pot uporabe:

PARENTERAL

Tip zastaranja:

PRESCRIPTION DRUG

Terapevtske indikacije:

In general, the most common uses of epinephrine are to relieve respiratory distress due to bronchospasm, to provide rapid relief of hypersensitivity reactions to drugs and other allergens, and to prolong the action of infiltration anesthetics. Its cardiac effects may be of use in restoring cardiac rhythm in cardiac arrest due to various causes, but is not used in cardiac failure or in hemorrhagic, traumatic, or cardiogenic shock. Epinephrine is used as a hemostatic agent. It is also used in treating mucosal congestion of hay fever, rhinitis, and acute sinusitis; to relieve bronchial asthmatic paroxysms; in syncope due to complete heart block or carotid sinus hypersensitivity; for symptomatic relief of serum sickness, urticaria, angioneurotic edema; for resuscitation in cardiac arrest following anesthetic accidents; in simple (open angle) glaucoma; for relaxation of uterine musculature and to inhibit uterine contractions. Epinephrine injection can be utilized to prolong the action of local anesthetics (see CON

Povzetek izdelek:

Epinephrine Injection, USP 1 mg/mL Packaged individually. NDC 76329-9061-0      30 mL Multiple Dose Vial     Stock No. 9061 Store at Controlled room temperature 15° to 25°C (59° to 77°F). Protect from light and freezing.

Status dovoljenje:

unapproved drug other

Lastnosti izdelka

EPINEPHRINE - EPINEPHRINE INJECTION
INTERNATIONAL MEDICATION SYSTEMS, LIMITED
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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EPINEPHRINE INJECTION, USP
DESCRIPTION:
Epinephrine Injection, USP, is a sterile, nonpyrogenic solution
intended for subcutaneous or
intramuscular injection. When diluted, it may also be administered
intracardially or intravenously. Each
mL contains: 1 mg Epinephrine as the hydrochloride, in Water for
Injection, USP, q.s. Sodium Chloride
added for isotonicity, 0.5% Chlorobutanol (chloroform derivative) as a
preservative and not more than
0.15% Sodium Metabisulfite as an antioxidant. The pH may be adjusted
with Sodium Hydroxide and/ or
Hydrochloric Acid. Epinephrine is the active principle of the adrenal
medulla, chemically described as
(-)-3,4-Dihydroxy-α-[(methylamino)methyl]benzyl alcohol, and has the
following structural formula:
CLINICAL PHARMACOLOGY:
Epinephrine is a sympathomimetic drug. It activates an adrenergic
receptive mechanism on effector
cells and imitates all actions of the sympathetic nervous system
except those on the arteries of the face
and sweat glands. Epinephrine acts on both alpha and beta receptors
and is the most potent alpha receptor
activator.
Epinephrine relaxes the smooth muscle of the bronchi and iris and is a
physiologic antagonist of
histamine. The drug also produces an increase in blood sugar and
glycogenolysis in the liver.
PHARMACOKINETICS :
Intravenous injection produces an immediate and intensified response.
Following I.V. injection,
epinephrine disappears rapidly from the blood stream. Subcutaneously
or I.M. administered epinephrine
has a rapid onset and short duration of action. Subcutaneous
administration during asthmatic attacks may
produce bronchodilation within 5 to 10 minutes, and maximal effects
may occur within 20 minutes.
The drug becomes fixed in the tissues and is rapidly inactivated
chiefly by