Država: Malezija
Jezik: angleščina
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Paracetamol; ORPHENADRINE CITRATE
DYNAPHARM (M) SDN BHD
Paracetamol; ORPHENADRINE CITRATE
50x10'stablet Tablets
DYNAPHARM (M) SDN BHD
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ DYCOSIC TABLET Orphenadrine citrate (35 mg) and Paracetamol (450 mg) What is in this leaflet 1. What _DYCOSIC_ is used for 2. How _DYCOSIC_ works 3. Before you use _DYCOSIC_ 4. How to use _DYCOSIC_ 5. While you are using it 6. Side effects 7. Storage and Disposal of _DYCOSIC_ 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision 1. WHAT DYCOSIC IS USED FOR Tension headache, occipital headaches associated with spasm of skeletal muscles in the region of the head and neck. Acute and traumatic conditions of the limbs and trunk: sprains, strains, whiplash injuries, acute torticollis, prolapsed intervertebral disc. 2. HOW DYCOSIC WORKS Orphenadrine is a skeletal muscle relaxant. Paracetamol is an analgesic and antipyretic. Orphenadrine, which is a congener of diphenhydramine without sharing its soporific effect, is an antimuscarinic agent. It also has weak antihistaminic and local anaesthetic properties. Paracetamol is a centrally acting analgesic and antipyretic with minimal anti-inflammatory properties. 3. BEFORE YOU USE DYCOSIC - _When you must not use it_ _ _ Glaucoma, prostatic hypertrophy or obstruction at the bladder neck, myasthenia gravis, oesophageal spasm and pyloric or duodenal obstruction. Hypersensitivity to paracetamol or orphenadrine citrate. _Pregnancy and lactation _ Use in pregnancy DYCOSIC is not recommended for use during pregnancy. Use in lactation DYCOSIC should not be taken during lactation as orphenadrine and paracetamol are excreted into breast milk. - _Taking other medicines _ Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop. Interactions have been reported between orphenadrine and phenothiazines and other drugs with anti-muscarinic properties. Concomitant use with alcohol or other CNS depressants should be avoided. Anticoagulant dosage may require reduction if paracetamol medication is prolonged. Par Preberite celoten dokument
MAL18056180AZ CONTENT Orphenadrine citrate 35 mg Paracetamol 450 mg. PHARMACODYNAMICS Orphenadrine, which is a congener of diphenhydramine without sharing its soporific effect, is a tertiary amine antimuscarinic with actions and uses similar to those of trihexyphenidyl. It also has weak antihistaminic and local anaesthetic properties. Paracetamol is a centrally acting analgesic and antipyretic with minimal anti-inflammatory properties. PHARMACOKINETICS Orphenadrine is readily absorbed from the gastro-intestinal tract, and very readily absorbed following intramuscular injection. It is rapidly distributed in tissues and most of a dose is metabolised and excreted in the urine along with a small proportion of unchanged drug. A half-life of 14 hours has been reported. Paracetamol is rapidly absorbed following oral administration. Paracetamol absorption takes place mainly in the small intestine and therefore the rate of absorption depends on the rate of gastric emptying. The presence of food in the stomach has also been reported to reduce the rate of absorption of paracetamol. Alterations in gastric pH have no appreciable effect on paracetamol absorption. Peak plasma concentrations are reached 1 hour after absorption. The plasma half-life is 1 to 3 hours. Paracetamol penetrates the brain and is present in breast milk of human. Paracetamol is metabolized by the microsomal enzyme system of the liver. This metabolism is mainly to the glucuronide and sulphate conjugates, accounting for approximately 49% and 26% of the ingested dose respectively. About 4% is excreted as free paracetamol. Other minor pathways include the production of catechol derivatives and cysteine conjugates (via glutathione). Paracetamol excretion is rapid and occurs via the urine. INDICATIONS Tension headache, occipital headaches associated with spasm of skeletal muscles in the region of the head and neck. Acute and traumatic conditions of the limbs and trunk: sprains, strains, whiplash injuries, acute torticollis, prolapsed intervertebral disc. DOSAGE Preberite celoten dokument