DEXAMETHASONE injection, solution

Država: Združene države Amerike

Jezik: angleščina

Source: NLM (National Library of Medicine)

Aktivna sestavina:

DEXAMETHASONE (UNII: 7S5I7G3JQL) (DEXAMETHASONE - UNII:7S5I7G3JQL)

Dostopno od:

MWI (Vet One)

Pot uporabe:

INTRAMUSCULAR

Tip zastaranja:

PRESCRIPTION

Terapevtske indikacije:

DEXAMETHASONE INJECTION 2 mg/mL is indicated for the treatment of primary bovine ketosis and as an anti-inflammatory agent in the bovine and equine. As supportive therapy, DEXAMETHASONE INJECTION 2 mg/mL may be used in the management of various rheumatic, allergic, dermatologic, and other diseases known to be responsive to anti-inflammatory corticosteroids. DEXAMETHASONE INJECTION 2 mg/mL may be used intravenously as supportive therapy when an immediate hormonal response is required. Bovine Ketosis DEXAMETHASONE INJECTION 2 mg/mL is offered for the treatment of primary ketosis. The gluconeogenic effects of DEXAMETHASONE INJECTION 2 mg/mL, when administered intramuscularly, are generally noted within the first 6 to 12 hours. When DEXAMETHASONE INJECTION 2 mg/mL is used intravenously, the effects may be noted sooner. Blood sugar levels rise to normal levels rapidly and generally rise to above normal levels within 12 to 24 hours. Acetone bodies are reduced to normal concentrations usually within 24 hours. The ph

Povzetek izdelek:

DEXAMETHASONE INJECTION 2 mg/mL 100 mL multiple dose vial 250 mL - NDC 13985-533-25 Store at 20o C to 25o C (68o F to 77o F), excursions permitted between 15o C and 30o C (between 59o F and 86o F). Protect from freezing. Approved by FDA under ANADA # 200-324

Status dovoljenje:

Abbreviated New Animal Drug Application

Lastnosti izdelka

DEXAMETHASONE- DEXAMETHASONE INJECTION, SOLUTION
MWI (VET ONE)
----------
DEXAMETHASONE INJECTION 2 MG/ML DEXAMETHASONE STERILE INJECTION
SOLUTION FOR INTRAVENOUS OR INTRAMUSCULAR INJECTION
VETERINARY
NOT FOR USE IN HUMANS
CAUTIONFederal Law restricts this drug to use by or on the order of a
licensed
veterinarian.
DESCRIPTION
DEXAMETHASONE INJECTION 2 mg/mL is a synthetic analogue of
prednisolone, having
similar but more potent anti-inflammatory therapeutic action and
diversified hormonal
and metabolic effects. Modification of the basic corticoid structure
as achieved in
DEXAMETHASONE INJECTION 2 mg/mL offers enhanced anti-inflammatory
effect
compared to older corticosteroids. The dosage of DEXAMETHASONE
INJECTION 2
mg/mL required is markedly lower than that of prednisone and
prednisolone.
DEXAMETHASONE INJECTION 2 mg/mL is not species-specific; however, the
veterinarian
should read the sections on INDICATIONS, DOSAGE, SIDE EFFECTS,
CONTRAINDICATIONS, PRECAUTIONS, and WARNINGS before this drug is used.
DEXAMETHASONE INJECTION 2 mg/mL is intended for _intravenous or
intramuscular_
administration. Each mL contains 2 mg dexamethasone, 500 mg
polyethylene glycol
400, 9 mg benzyl alcohol, 1.8 mg methylparaben and 0.2 mg
propylparaben as
preservatives, 4.75% alcohol, HCl to adjust pH to approximately 4.9,
water for injection
q.s.
EXPERIMENTAL STUDIES
Experimental animal studies on dexamethasone have revealed it
possesses greater anti-
inflammatory activity than many steroids. Veterinary clinical evidence
indicates
dexamethasone has approximately twenty times the anti-inflammatory
activity of
prednisolone and seventy to eighty times that of hydrocortisone.
Thymus involution
studies show dexamethasone possesses twenty-five times the activity of
prednisolone.
In reference to mineralocorticoid activity, dexamethasone does not
cause significant
sodium or water retention. Metabolic balance studies show that animals
on controlled
and limited protein intake will exhibit nitrogen losses on exceedingly
high dosages.
INDICATIONS