bal in oil- Dimercaprol injection

Država: Združene države Amerike

Jezik: angleščina

Source: NLM (National Library of Medicine)

Aktivna sestavina:

Dimercaprol (UNII: 0CPP32S55X) (Dimercaprol - UNII:0CPP32S55X)

Dostopno od:

Taylor Pharmaceuticals

INN (mednarodno ime):

Dimercaprol

Farmacevtska oblika:

INJECTION

Sestava:

100 mg in 1 mL

Pot uporabe:

INTRAMUSCULAR

Tip zastaranja:

PRESCRIPTION DRUG

Terapevtske indikacije:

BAL in Oil (Dimercaprol Injection USP) is indicated in the treatment of arsenic, gold and mercury poisoning. It is indicated in acute lead poisoning when used concomitantly with Edetate Calcium Disodium Injection USP. Dimercaprol Injection USP is effective for use in acute poisoning by mercury salts if therapy is begun within one or two hours following ingestion. It is not very effective for chronic mercury poisoning. Dimercaprol Injection USP is of questionable value in poisoning caused by other heavy metals such as antimony and bismuth. It should not be used in iron, cadmium, or selenium poisoning because the resulting dimercaprol-metal complexes are more toxic than the metal alone, especially to the kidneys. BAL in Oil (Dimercaprol Injection USP) is contraindicated in most instances of hepatic insufficiency with the exception of postarsenical jaundice. The drug should be discontinued or used only with extreme caution if acute renal insufficiency develops during therapy. Dimercaprol Injection USP is not a c

Povzetek izdelek:

3 mL (100 mg/mL) ampules, box of 10 (NDC 11098-526-03). Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature.]

Lastnosti izdelka

BAL IN OIL- DIMERCAPROL INJECTION
TAYLOR PHARMACEUTICALS
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BAL IN OIL AMPULES
DIMERCAPROL INJECTION, USP
BAL (2, 3-dimercapto-1-propanol) 10%, Benzyl Benzoate 20%, in Peanut
Oil
C H OS Molecular Weight 124.22
RX ONLY
DESCRIPTION
Dimercaprol Injection USP is a colorless or almost colorless liquid
chelating agent having a
disagreeable, mercaptan-like odor. Each 1 mL sterile BAL in Oil
(Dimercaprol Injection USP) contains:
100 mg Dimercaprol in 200 mg Benzyl Benzoate and 700 mg Peanut Oil.
CLINICAL PHARMACOLOGY
The sulfhydryl groups of dimercaprol form complexes with certain heavy
metals thus preventing or
reversing the metallic binding of sulfhydryl-containing enzymes. The
complex is excreted. The
sustained presence of dimercaprol promotes continued excretion of the
metallic poisons - arsenic, gold
and mercury. It is also used in combination with Edetate Calcium
Disodium Injection USP to promote the
excretion of lead.
INDICATIONS
BAL in Oil (Dimercaprol Injection USP) is indicated in the treatment
of arsenic, gold and mercury
poisoning. It is indicated in acute lead poisoning when used
concomitantly with Edetate Calcium
Disodium Injection USP.
Dimercaprol Injection USP is effective for use in acute poisoning by
mercury salts if therapy is begun
within one or two hours following ingestion. It is not very effective
for chronic mercury poisoning.
Dimercaprol Injection USP is of questionable value in poisoning caused
by other heavy metals such as
antimony and bismuth. It should not be used in iron, cadmium, or
selenium poisoning because the
resulting dimercaprol-metal complexes are more toxic than the metal
alone, especially to the kidneys.
CONTRAINDICATIONS
BAL in Oil (Dimercaprol Injection USP) is contraindicated in most
instances of hepatic insufficiency
with the exception of postarsenical jaundice. The drug should be
discontinued or used only with
extreme caution if acute renal insufficiency develops during therapy.
3
8
2
WARNINGS
There may be local pain at the site of the injection. A reaction
apparently