AVO LIQUID GEL

Država: Malezija

Jezik: angleščina

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktivna sestavina:

LIDOCAINE HYDROCHLORIDE; Benzalkonium Chloride Solution; CHOLINE SALICYLATE

Dostopno od:

APEX PHARMACY MARKETING SDN. BHD.

INN (mednarodno ime):

LIDOCAINE HYDROCHLORIDE; Benzalkonium Chloride Solution; CHOLINE SALICYLATE

Enote v paketu:

15gm mcg/mL

Izdeluje:

GROUP PHARMACEUTICALS LTD

Lastnosti izdelka

AVO LIQUID GEL
COMPOSITION
Avo Liquid Gel contains:
Choline Salicylate Solution equivalent to Choline Salicylate 8.7%w/w
Benzalkonium Chloride Solution 0.01%w/w
Lidocaine Hydrochloride 2%w/w
DESCRIPTION
Light brown coloured gel with a pleasant flavour.
PHARMACODYNAMIC
Choline salicylate is the choline salt of salicylic acid and its
pharmacology is
essentially that of salicylic acid. It has exhibited anti-inflammatory
analgesic and
antipyretic actions in animal models, and is taken orally or is
applied topically in man
for the relief of pain and inflammation. Like salicylic acid, it has
no antithrombotic
activity and shows a low potential for production of gastrointestinal
injury when given
by the oral route. The pharmacological actions of choline salicylate
are thought to be
primarily mediated through inhibition of prostaglandin production,
although effects
on lukotriene pathways, kinin release and nerve conduction have been
proposed.
PHARMACOKINETIC
Choline salicylate is absorbed from the gut and is likely to be
absorbed across mucous
membranes such as all buccal mucosa. Metabolism of salicylic acid is
by glycine and
phenolic or acyl glucuronate conjugation with small amounts undergoing
hydroxylation. The plasma half-life of salicylic acid is 2-4 hours.
Both metabolites
and a small amount of intact salicylic acid are excreted, mainly in
the urine. Salicylic
acid is highly (80-90%) protein bound and although it has a low
apparent volume of
distribution of around 0.151 l/kg it is widely distributed throughout
extracellular water
and most tissues.
INDICATION
For the temporary relief of pain caused by recurrent mouth ulcers,
denture irritation.
RECOMMENDED DOSE
Adults and the elderly: apply a small amount to the affected area with
a clean
fingertip. One application should be sufficient. Use up to four times
a day.
CONTRAINDICATION
Hypersensitivity to any of the ingredients of the formula
Allergic to salicylates eg: Aspirin.
Allergic to lignocaine.
Active peptic ulcer.
Herpes infection and influenza in childhood.
Not