Država: Malezija
Jezik: angleščina
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Methadone HCl
MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.
Methadone HCl
1000 ml mL; 100 ml mL
MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.
_Consumer Medication Information Leaflet (RiMUP) _ __________________________________________________________________________________________________________ 1 ADECURE SYRUP 5MG/ML Methadone Hydrochloride (5mg/ml) WHAT IS IN THIS LEAFLET: 1. What Adecure Syrup is used for 2. How Adecure Syrup works 3. Before you take Adecure Syrup 4. How to take Adecure Syrup 5. While you are taking Adecure Syrup 6. Side Effects 7. Storage and Disposal of Adecure Syrup 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT ADECURE SYRUP IS USED FOR Methadone Hydrochloride is the active ingredient of Adecure Syrup 5mg/ml. It is indicated for detoxification treatment or maintenance treatment of narcotic addiction. HOW ADECURE SYRUP WORKS? It is a primarily a μ opioid agonist with actions similar to morphine involving the central nervous system and organs composed of smooth muscle. BEFORE YOU TAKE ADECURE SYRUP _- When you must not take it _ If you have known hypersensitivity to methadone or any other ingredients of Adecure Syrup. If you have suffering from respiratory depression (slow, shallow breathing), lung disease or any illness causing difficulty in breathing If you are suffering from ulcerative colitis (inflammed bowel disorder) If you have severe liver problem If you are taking, or have taken in the last two weeks depression medication known as Monoamine Oxidase Inhibitors (MAOIs) If you have acute asthma attack, acute alcoholism, risk of paralytic ileus (severe constipation or bowel obstruction) or raised intracranial pressure or head injury. _- Before you start to take it _ You must tell your doctor if: you have allergies to any medicine which you have taken previously to treat your current condition. you are pregnant, trying to become pregnant or breast-feeding. You have asthma and/or respiratory problem. You have head injury and/or increased intracranial pressure You have anxiety problem You need to drive or operate machinery Y Preberite celoten dokument
7185-06 ADECURE SYRUP 5MG/ML NAME AND STRENGTH OF ACTIVE INGREDIENT(S): Each ml contains: Methadone Hydrochloride………………………………………………5mg PRODUCT DESCRIPTION: A red colour liquid. PHARMACODYNAMICS : Methadone is primarily a μ opioid agonist with multiple actions quantitatively similar to those of morphine, the most prominent of which involve the central nervous system and organs composed of smooth muscle. PHARMACOKINETICS: Methadone is well absorbed from the gastrointestinal tract. Oral administration of methadone delays its onset of action, lowers its peak concentrations, prolongs its duration of action and reduces its potency by about half compared to parenteral administration. When administered orally, its onset of action is 30-60 minutes, duration of action 4-6 hours and the time taken to reach its peak effect is 1.5-2 hours. The duration of action of methadone is extended in patients physically dependent on oral methadone. Repeated administration of methadone increases its duration of action to approximately 22- 48 hours in patients on methadone maintenance because of the accummulation of methadone or active metabolites. This may decrease as tolerance develops with chronic treatment. The depressant effects from methadone overdosage may continue for 36-48 hours. Methadone is highly bound to tissue protein. This may explain its cummulative effects and slow elimination. The half-life of orally administered methadone is 13-47 hours, with an average of 25 hours. This may increase with repeated administration. Methadone is primarily metabolized in the liver where it undergoes N-demethylation and does not appear to be conjugated. It is mainly excreted renally and undergoes renal reabsorption. The renal excretion of methadone is dose dependent and also increases when renal reabsorption decreases in acidic urine. Methadone metabolities are also excreted in the faeces via the bile. Methadone abstinence syndrome is qualitatively similar to that of morphine but has a slower onset, a mor Preberite celoten dokument