Država: Združene države Amerike
Jezik: angleščina
Source: NLM (National Library of Medicine)
ACYCLOVIR (UNII: X4HES1O11F) (ACYCLOVIR - UNII:X4HES1O11F)
Renaissance Pharma, Inc.
ACYCLOVIR
ACYCLOVIR 200 mg in 5 mL
ORAL
PRESCRIPTION DRUG
Herpes Zoster Infections: Acyclovir is indicated for the acute treatment of herpes zoster (shingles). Genital Herpes: Acyclovir is indicated for the treatment of initial episodes and the management of recurrent episodes of genital herpes. Chickenpox: Acyclovir is indicated for the treatment of chickenpox (varicella). Acyclovir is contraindicated for patients who develop hypersensitivity to acyclovir or valacyclovir.
Acyclovir Suspension (off-white, banana-flavored) containing 200 mg acyclovir in each teaspoonful (5 mL). Bottle of 1 pint (473 mL) (NDC 40085-842-96). Store at 15° to 25°C (59° to 77°F). Manufactured for: Renaissance Pharma, Inc. Newtown, PA 18940 by Glaxosmithkline Mississauga, ON, CANADA March 2014
New Drug Application Authorized Generic
ACYCLOVIR- ACYCLOVIR SUSPENSION RENAISSANCE PHARMA, INC. ---------- ACYCLOVIR SUSPENSION PRESCRIBING INFORMATION ACYCLOVIR SUSPENSION DESCRIPTION Acyclovir is a synthetic nucleoside analogue active against herpesviruses. Acyclovir Suspension is a formulation for oral administration. Each teaspoonful (5 mL) of Acyclovir Suspension contains 200 mg of acyclovir and the inactive ingredients methylparaben 0.1% and propylparaben 0.02% (added as preservatives), carboxymethylcellulose sodium, avor, glycerin, microcrystalline cellulose, and sorbitol. Acyclovir is a white, crystalline powder with the molecular formula C H N O and a molecular weight of 225. The maximum solubility in water at 37°C is 2.5 mg/mL. The pka’s of acyclovir are 2.27 and 9.25. The chemical name of acyclovir is 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy) methyl]-6_H_-purin-6- one; it has the following structural formula: VIROLOGY MECHANISM OF ANTIVIRAL ACTION: Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of acyclovir is highly selective due to its afnity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In vitro, acyclovir triphosphate stops replication of herpes viral DNA. This is accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared with VZV is due to its more efcient phosphorylation by the viral TK. ANTIVIRAL ACTIVITIES: The quantitative relationship between the in vitro susceptibility of herpes viruses to antivirals and the clinical re Preberite celoten dokument