Triftazine

Krajina: Arménsko

Jazyk: angličtina

Zdroj: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում

Aktívna zložka:

trifluoperazine (trifluoperazine hydrochloride)

Dostupné z:

Arpimed LLC

INN (Medzinárodný Name):

trifluoperazine (trifluoperazine hydrochloride)

Dávkovanie:

5mg

Forma lieku:

tablets coated

Typ predpisu:

Prescription

Súhrn charakteristických

SUMMARY PRODUCT CHARACTERISTIC (SPC)
TRIFTAZINE
5 MG COATED TABLETS
BRAND NAME - Triftazine
GENERIC NAME – Trifluoperazine
COMPOSITION
Each coated tablet_ of Triftazine _contains:
_ACTIVE INGREDIENT: _trifluoperazine – 5 mg (trifluoperazine
hydrochloride – 6) mg;
_INACTIVE INGREDIENTS:_ tablet core: microcrystalline cellulose,
lactose monohydrate, povidone, maize
starch, sodium starch glycolate, magnesium stearate, talc purified;
tablet coating: hypromellose,
titanium dioxide, propylene glycol, color blue (brilliant blue).
CHEMICAL NAME AND CAS NUMBER
10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10_H_phenothiazine
dihydrochloride;
440-17-5.
PHARMACOLOGICAL GROUP AND ATC CODE
A phenothiazine antipsychotic; N05AВ06.
PHARMACOLOGY
Trifluoperazine
is
one
of
the
phenothiazine
class
of
compounds
and
as
such
has
many
pharmacodynamic effects which relate to its therapeutic actions and
side effects. The most notable
action of phenothiazines is antagonism at dopamine receptors in the
CNS. It is hypothesised that
this action in the limbic system and associated areas of cerebral
cortex is the basis of the
antipsychotic action of phenothiazines, whilst in the medullary
chemoreceptor trigger zone it
appears
to
be
responsible
for
the
antiemetic
effect
of
these
agents.
In
addition,
dopamine
antagonism in the basal ganglia appears to be involved in some of the
extrapyramidal side-effects of
phenothiazines, whilst blockage of the dopaminergic inhibition of
prolactin release
from the
anterior pituitary gland is thought to lead to hyperprolactinaemia.
Other central actions of phenothiazines include sedation and
inhibition of the function of the
hypothalmic heat regulatory centre. Phenothiazines also lower the
seizure threshold. Central actions
of phenothiazines also affect the cardiovascular system, as does their
antagonism of peripheral α -
adrenergic receptors, which can cause hypotension.
Phenothiazines also have anti – muscarinic activity which causes
certain side effects.
Trifluoperazine is one of the pipe