Timoptol-XE

Krajina: Austrália

Jazyk: angličtina

Zdroj: Department of Health (Therapeutic Goods Administration)

Aktívna zložka:

Timolol maleate

Dostupné z:

Merck Sharp & Dohme Australia Pty Ltd

Trieda:

Medicine Registered

Príbalový leták

TIMOPTOL-XE
®

_Timolol maleate_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about TIMOPTOL-XE. It
does not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using TIMOPTOL-
XE against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
USING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT TIMOPTOL-XE IS
USED FOR
TIMOPTOL-XE is used to lower
raised pressure in the eye and to treat
glaucoma. Glaucoma is a condition
in which the pressure of fluid in the
eye may be high. However, some
people with glaucoma may have
normal eye pressure. Also, some
people with raised eye pressure may
not have glaucoma.
Glaucoma is usually caused by a
build-up of the fluid which flows
through the eye. This build up occurs
because the fluid drains out of your
eye more slowly than it is being
pumped in. Since new fluid continues
to enter the eye, joining the fluid
already there, the pressure continues
to rise. This raised pressure may
damage the back of the eye resulting
in gradual loss of sight. Damage can
progress so slowly that the person is
not aware of this gradual loss of
sight. Sometimes even normal eye
pressure is associated with damage to
the back of the eye.
There are usually no symptoms of
glaucoma. The only way of knowing
that you have glaucoma is to have
your eye pressure, optic nerve and
visual field checked by an eye
specialist or optometrist. If glaucoma
is not treated it can lead to serious
problems. You may have no
symptoms but eventually glaucoma
can lead to total blindness. In fact,
untreated glaucoma is one of the
most common causes of blindness.
Although TIMOPTOL-XE helps
control your glaucoma it does not
cure it.
For more information about
glaucoma, contact Glaucoma
Australia Inc., PO Box 420, Crows
Nest 1585, telephon

Súhrn charakteristických

IPC- GFS-092012 
1 

PRODUCT INFORMATION 

TIMOPTOL-XE


(timolol maleate, MSD) 

Sterile Ophthalmic Gellan Solution  

CHEMISTRY 

Timolol maleate is
a beta-adrenergic receptor blocking agent.  The chemical name
is (_S_)-1-
[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol (Z)-2-
butenedioate (1:1) (salt).  Timolol maleate
possesses an asymmetric carbon atom and is 
provided as the levo isomer.  The empirical formula is
C13H24N403S.C4H404 and the 
structural formula is: 

Timolol maleate has a molecular weight of 432.50.  It is a
white, odourless, crystalline 
powder which is soluble in water, methanol, and alcohol. 

DESCRIPTION 

TIMOPTOL-XE* (timolol maleate, MSD) Sterile
Ophthalmic Gellan Solution is a formulation 
of timolol maleate (TIMOPTOL) containing gellan gum.  

Gellan gum is a
highly purified anionic heteropolysaccharide.  Aqueous solutions
of gellan 
gum form a clear transparent gel at low polymer concentrations
in the presence of cations.  
When
TIMOPTOL-XE contacts the precorneal tear film, it becomes a
gel. The concentration 
of sodium cation in tears is ideally suited to cause gelation
of the material when topically 
instilled in the conjunctival sac. 


 Registered Trademark of Merck & Co., Inc., Whitehouse
Station, N.J., U.S.A. 
IPC- GFS-092012 
2 

Each mL of TIMOPTOL-XE 0.25% contains
2.5mg of timolol (3.4mg of timolol maleate).  
Each mL of TIMOPTOL-XE 0.5% contains
5.0mg of timolol (6.8mg of timolol maleate).  
TIMOPTOL-XE also contains the following inactive
ingredients: gellan gum, trometamol, 
mannitol and
water for injection. Benzododecinium bromide 0.012% is added
as the 
preservative. 

PHARMACOLOGY 

TIMOPTOL-XE reduces elevated and
normal intraocu