TEVA-DILTIAZEM CD CAPSULE (EXTENDED RELEASE)

Krajina: Kanada

Jazyk: angličtina

Zdroj: Health Canada

Aktívna zložka:

DILTIAZEM HYDROCHLORIDE

Dostupné z:

TEVA CANADA LIMITED

ATC kód:

C08DB01

INN (Medzinárodný Name):

DILTIAZEM

Dávkovanie:

240MG

Forma lieku:

CAPSULE (EXTENDED RELEASE)

Zloženie:

DILTIAZEM HYDROCHLORIDE 240MG

Spôsob podávania:

ORAL

Počet v balení:

100/500

Typ predpisu:

Prescription

Terapeutické oblasti:

MISCELLANEOUS CALCIUM-CHANNEL BLOCKING AGENTS

Prehľad produktov:

Active ingredient group (AIG) number: 0115863006; AHFS:

Stav Autorizácia:

APPROVED

Dátum Autorizácia:

2000-10-04

Súhrn charakteristických

1
PRODUCT MONOGRAPH
PR
TEVA-DILTIAZEM CD
diltiazem hydrochloride
Controlled Delivery Capsules
Teva Standard
120 mg, 180 mg, 240 mg and 300 mg
Antihypertensive Agent
Antianginal Agent
Teva Canada Limited
Date of Revision:
30 Novopharm Court
May 06, 2016
Toronto, Ontario
M1B 2K9
www.tevacanada.com
Control # 194512
2
PR
TEVA-DILTIAZEM CD
diltiazem hydrochloride
Controlled Delivery Capsules
Teva Standard
120 MG, 180 MG, 240 MG AND 300 MG
ANTIHYPERTENSIVE AGENT
ANTIANGINAL AGENT
ACTION AND CLINICAL PHARMACOLOGY
TEVA-DILTIAZEM CD capsules are formulations of diltiazem
hydrochloride, which is a
calcium ion influx inhibitor (calcium entry blocker or calcium ion
antagonist).
MECHANISM OF ACTION
The therapeutic effect of diltiazem is believed to be related to its
specific cellular action of
selectively inhibiting transmembrane influx of calcium ions into
cardiac muscle and vascular
smooth muscle. The contractile processes of these tissues are
dependent upon the movement of
extracellular calcium into the cells through specific ion channels.
Diltiazem blocks
transmembrane influx of calcium through the slow channel without
affecting to any significant
degree the transmembrane influx of sodium through the fast channel.
This results in a reduction
of free calcium ions available within cells of the above tissues.
Diltiazem does not alter total
serum calcium.
ANGINA: The precise mechanism by which diltiazem relieves angina has
not been fully
determined but it is believed to be brought about largely by its
vasodilator action.
In angina due to coronary spasm, diltiazem increases myocardial oxygen
delivery by dilating
both large and small coronary arteries and by inhibiting coronary
spasm at drug levels which
cause little negative inotropic effect. The resultant increases in
coronary blood flow are
accompanied by dose dependent decreases in systemic blood pressure and
decreases in
peripheral resistance.
In angina of effort, it appears that the action of diltiazem is
related to the reduction of myocardial
oxygen demand. This is proba