Krajina: Malajzia
Jazyk: angličtina
Zdroj: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
PRAZIQUANTEL; PYRANTEL PAMOATE; FEBANTEL
KM Vet Pharm Sdn Bhd
PRAZIQUANTEL; PYRANTEL PAMOATE; FEBANTEL
2 x 10 Tablets
M/s. Smith & Kenner Pharmaceuticals Pvt. Ltd
For the use only of a Veterinary Medical Practitioner or a Hospital or a Laboratory or a farm Praziquantel, Pyrantel Pamoate & Febantel Tablets PRAZIVET PLUS COMPOSITION: EACH UNCOATED TABLET CONTAINS Praziquantel USP 50mg Pyrantel Pomoate USP 144mg Febantel 150mg PRODUCT DESCRIPTION Pale Yellow Coloured Uncoated Tablets PHARMACODYNAMICS This product contains anthelmintics active against gastrointestinal roundworms and tapeworms. The product contains three active substances: 1. Febantel, a probenzimidazole, 2. Pyrantel embonate (pamoate) a tetrahydropyrimidine derivative, 3. Praziquantel, a partially hydrogenated pyrazinoisoquinoline derivative _ATC VetCode_: QP52AF30 In this fixed combination pyrantel and febantel act against all relevant nematodes (ascarids, hookworms, and whipworms) in dogs. In particular the activity spectrum covers Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum and Trichuris vulpis. This combination shows synergistic activity in the case of hookworms and febantel is effective against T. vulpis. The spectrum of activity of praziquantel covers all important cestode species in dogs, in particular Taenia spp; Dipylidium caninum; Echinococcus granulosus and Echinococcus multilocularis. Praziquantel acts against all adult and immature forms of these parasites. Praziquantel is very rapidly absorbed through the parasite’s surface and distributed throughout the parasite. Both in vitro and in vivo studies have shown that praziquantel causes severe damage to the parasite integument, resulting in the contraction and paralysis of the parasites. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium. Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis of the nematodes and thereby allow removal from th Prečítajte si celý dokument