OXYBUTYNIN CHLORIDE tablet

Krajina: Spojené štáty

Jazyk: angličtina

Zdroj: NLM (National Library of Medicine)

Aktívna zložka:

OXYBUTYNIN CHLORIDE (UNII: L9F3D9RENQ) (OXYBUTYNIN - UNII:K9P6MC7092)

Dostupné z:

McKesson Contract Packaging

INN (Medzinárodný Name):

OXYBUTYNIN CHLORIDE

Zloženie:

OXYBUTYNIN CHLORIDE 5 mg

Typ predpisu:

PRESCRIPTION DRUG

Stav Autorizácia:

Abbreviated New Drug Application

Súhrn charakteristických

OXYBUTYNIN CHLORIDE- OXYBUTYNIN CHLORIDE TABLET
MCKESSON CONTRACT PACKAGING
----------
OXYBUTYNIN CHLORIDE TABLETS, USP
RX ONLY
DESCRIPTION
Each scored oxybutynin chloride tablet contains 5 mg of oxybutynin
chloride, USP.
Chemically, oxybutynin chloride is d,l (racemic)
4-diethylamino-2-butynyl phenylcyclohexylglycolate
hydrochloride. The empirical formula of oxybutynin chloride is C
H NO •HCl. The structural
formula appears below:
Oxybutynin chloride is a white crystalline solid with a molecular
weight of 393.9. It is readily soluble
in water and acids, but relatively insoluble in alkalis.
Oxybutynin Chloride Tablets also contain: FD&C Blue #1 aluminum lake,
magnesium stearate,
microcrystalline cellulose, and pregelatinized starch.
Oxybutynin Chloride Tablets are for oral administration.
Therapeutic Category: Antispasmodic, anticholinergic.
CLINICAL PHARMACOLOGY
Oxybutynin chloride exerts a direct antispasmodic effect on smooth
muscle and inhibits the muscarinic
action of acetylcholine on smooth muscle. Oxybutynin chloride exhibits
only one-fifth of the
anticholinergic activity of atropine on the rabbit detrusor muscle,
but four to ten times the antispasmodic
activity. No blocking effects occur at skeletal neuromuscular
junctions or autonomic ganglia
(antinicotinic effects).
Oxybutynin chloride relaxes bladder smooth muscle. In patients with
conditions characterized by
involuntary bladder contractions, cystometric studies have
demonstrated that oxybutynin chloride
increases bladder (vesical) capacity, diminishes the frequency of
uninhibited contractions of the
detrusor muscle, and delays the initial desire to void. Oxybutynin
chloride thus decreases urgency and
the frequency of both incontinent episodes and voluntary urination.
Antimuscarinic activity resides predominately in the R-isomer. A
metabolite, desethyloxybutynin, has
pharmacological activity similar to that of oxybutynin in _in vitro_
studies.
PHARMACOKINETICS
_ABSORPTION_
22
31
3
Following oral administration of oxybutynin chloride, oxybutynin is
ra