Krajina: Južná Afrika
Jazyk: angličtina
Zdroj: South African Health Products Regulatory Authority (SAHPRA)
Bm_squib
KENACOMB CREAM KENACOMB OINTMENT SCHEDULING STATUS: S4 PP Zimbabwe only Reg No:E4/13.4.1/273 PROPRIETARY NAME (and dosage form) KENACOMB CREAM KENACOMB OINTMENT COMPOSITION Each gram contains 100 000 units nystatin , 2,5 mg neomycin base (as sulphate), 0,25 mg gramicidin , and 1,0 mg triamcinolone acetonide. KENACOMB CREAM is preserved with methylparaben 0,2% and propylparaben 0,02% PHARMACOLOGICAL CLASSIFICATION Category A 13.4.1 Corticosteroids with or without anti-infective agents. PHARMACOLOGICAL ACTION KENACOMB combines the potent corticosteroid triamcinolone acetonide with the antifungal antibiotic nystatin and the wide spectrum antibacterial activity of neomycin and gramicidin. KENACOMB reduces inflammation, relieves pruritis and combats or prevents monilial and bacterial infections. Pharmacokinetics The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin, inflammation and/or other disease processes in the skin increase percutaneous absorption. Nystatin and gramicidin are not absorbed from intact skin or mucous membranes. Neomycin can be absorbed through inflamed skin. Once absorbed, it is rapidly excreted unchanged through the kidneys. The half-life is approximately 2 to 3 hours. Microbiology Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. Nystatin exhibits no activity against bacteria, protozoa, or viruses. Neomycin exerts its bacterial activity against a number of gram-negative organisms by inhibiting protein synthesis. It is not active against Pseudomonas Prečítajte si celý dokument