heparin sodium- Heparin Sodium injection, solution

Krajina: Spojené štáty

Jazyk: angličtina

Zdroj: NLM (National Library of Medicine)

Aktívna zložka:

Heparin Sodium (UNII: ZZ45AB24CA) (Heparin - UNII:T2410KM04A)

INN (Medzinárodný Name):

Heparin Sodium

Forma lieku:

INJECTION, SOLUTION

Spôsob podávania:

INTRAVENOUS

Typ predpisu:

PRESCRIPTION DRUG

Terapeutické indikácie:

Heparin Sodium Injection is indicated for: Anticoagulant therapy in prophylaxis and treatment of venous thrombosis and its extension; (In a low-dose regimen) for prevention of postoperative deep venous thrombosis and pulmonary embolism in patients undergoing major abdomino-thoracic surgery or who for other reasons are at risk of developing thromboembolic disease (see DOSAGE AND ADMINISTRATION); Prophylaxis and treatment of pulmonary embolism; Atrial fibrillation with embolization; Diagnosis and treatment of acute and chronic consumption coagulopathies (disseminated intravascular coagulation); Prevention of clotting in arterial and heart surgery; Prophylaxis and treatment of peripheral arterial embolism; As an anticoagulant in blood transfusions, extracorporeal circulation, and dialysis procedures and in blood samples for laboratory purposes. Heparin sodium should not be used in patients: With severe thrombocytopenia; In whom suitable blood coagulation tests—e.g., the whole-blood clotting time, partial thrombo

Prehľad produktov:

Heparin Sodium Injection, USP derived from beef lung is available in the following strengths and package sizes: Store the product at controlled room temperature 20° to 25°C (68° to 77°F) [see USP].

Súhrn charakteristických

HEPARIN SODIUM- HEPARIN SODIUM INJECTION, SOLUTION
----------
HEPARIN SODIUM
INJECTION, USP
from beef lung
DESCRIPTION
Heparin is a heterogenous group of straight-chain anionic
mucopolysaccharides, called
glycosaminoglycans having anticoagulant properties. Although others
may be present, the main sugars
occurring in heparin are: (1) α-L-iduronic acid 2-sulfate, (2)
2-deoxy-2-sulfamino-α-D-glucose 6-
sulfate, (3) β-D-glucuronic acid, (4)
2-acetamido-2-deoxy-α-D-glucose, and (5) α-L-iduronic acid.
These sugars are present in decreasing amounts, usually in the order
(2) > (1) > (4) > (3) > (5), and are
joined by glycosidic linkages, forming polymers of varying sizes.
Heparin is strongly acidic because
of its content of covalently linked sulfate and carboxylic acid
groups. In heparin sodium, the acidic
protons of the sulfate units are partially replaced by sodium ions.
Structure of Heparin Sodium (representative subunits):
Heparin Sodium Injection, USP is a sterile solution of heparin sodium
derived from bovine lung tissue,
standardized for anticoagulant activity. It is to be administered by
intravenous or deep subcutaneous
routes. The potency is determined by a biological assay using a USP
reference standard based on units
of heparin activity per milligram. Heparin is pyrogen-free.
Each mL of the 1,000 and 5,000 USP Units per mL preparations contains:
heparin sodium 1,000 or
5,000 USP Units; 9 mg sodium chloride; 9.45 mg benzyl alcohol added as
preservative. Each mL of the
10,000 USP Units per mL preparations contains: heparin sodium 10,000
USP Units; 9.45 mg benzyl
alcohol added as preservative.
When necessary, the pH of Heparin Sodium Injection, USP was adjusted
with hydrochloric acid and/or
sodium hydroxide. The pH range is 5.0–7.5.
CLINICAL PHARMACOLOGY
Heparin inhibits reactions that lead to the clotting of blood and the
formation of fibrin clots both _in vitro_
and _in vivo_. Heparin acts at multiple sites in the normal
coagulation system. Small amounts of heparin in
combination with antithrombin III (h