GLYCOPYRROLATE INJECTION MULTIDOSE SOLUTION

Krajina: Kanada

Jazyk: angličtina

Zdroj: Health Canada

Aktívna zložka:

GLYCOPYRROLATE

Dostupné z:

OMEGA LABORATORIES LIMITED

ATC kód:

A03AB02

INN (Medzinárodný Name):

GLYCOPYRRONIUM

Dávkovanie:

0.2MG

Forma lieku:

SOLUTION

Zloženie:

GLYCOPYRROLATE 0.2MG

Spôsob podávania:

INTRAMUSCULAR

Počet v balení:

20ML

Typ predpisu:

Ethical

Terapeutické oblasti:

ANTIMUSCARINICS ANTISPASMODICS

Prehľad produktov:

Active ingredient group (AIG) number: 0102396002; AHFS:

Stav Autorizácia:

APPROVED

Dátum Autorizácia:

2012-04-03

Súhrn charakteristických

PRODUCT MONOGRAPH
GLYCOPYRROLATE INJECTION MULTIDOSE
0.2 MG / ML
(CONTAINS BENZYL ALCOHOL)
ANTICHOLINERGIC
FOR INTRAMUSCULAR OR INTRAVENOUS ADMINISTRATION
STERILE SOLUTION FOR INJECTION
Omega Laboratories, Ltd.
11 177 Hamon
Montreal, Canada
H3M 3E4
Submission Control No. 194739
Date of Revision: SEPTEMBER 27, 2016
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GLYCOPYRROLATE INJECTION MULTIDOSE
0.2 MG / ML
THERAPEUTIC CLASSIFICATION
Anticholinergic
ACTION AND CLINICAL PHARMACOLOGY
Glycopyrrolate, like other anticholinergic (antimuscarinic) agents,
competitively antagonizes the
action of acetylcholine on structures innervated by postganglionic
cholinergic nerves and on
smooth muscles that respond to acetylcholine but lack cholinergic
innervation.
Glycopyrrolate
antagonizes
muscarinic
symptoms
(e.g.,
bronchorrhea,
bronchospasm,
bradycardia
and
intestinal
hypermotility)
induced
by
cholinergic
drugs
such
as
anticholinesterases.
As a premedicant, Glycopyrrolate Injection reduces excessive
pharyngeal, tracheal and bronchial
secretions
and,
during
anesthesia,
it
appears
to
protect
the
heart
against
excessive
vagal
stimulation.
The polar ammonium moiety of glycopyrrolate limits its passage across
lipid membranes such as
the blood-brain barrier, in contrast to the belladonna alkaloids (such
as atropine), which are
nonpolar tertiary amines. Consequently, Glycopyrrolate Injection does
not cause the central
nervous system effects seen with the belladonna alkaloids.
The onset of action following intramuscular injection of injectable
glycopyrrolate is 20 to 40
minutes. Peak effects occur approximately 30 to 45 minutes after
administration and the
duration of action ranges from 4 to 6 hours. With intravenous
injection, the onset of action is
generally evident within one minute; the duration of action varies, as
does that of all other
anticholinergics. Following intravenous glycopyrrolate, the vagal
blocking effects persist for 2
to 3 hours and the antisialagogue effects persist up to 7 hours.
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INDICATIONS
GASTROINTESTINAL DISORDERS: Glycopyrrolate Injection may b