Krajina: Spojené štáty
Jazyk: angličtina
Zdroj: NLM (National Library of Medicine)
GENTAMICIN SULFATE (UNII: 8X7386QRLV) (GENTAMICIN - UNII:T6Z9V48IKG)
Aspen Veterinary Resources, Ltd.
GENTAMICIN SULFATE
GENTAMICIN 100 mg in 1 mL
INTRAUTERINE
PRESCRIPTION
For intra-uterine use in horses only. Gentamicin Sulfate Solution is recommended for the control of bacterial infections of the uterus (metritis) in horses and as an aid in improving conception in mares with uterine infections caused by bacteria sensitive to gentamicin. Bacteriologic studies should be conducted to identify the causative organism and to determine its sensitivity to gentamicin sulfate. Sensitivity discs of the drug are available for this purpose. There are no known contraindications to this drug when used as directed.
Gentamicin Sulfate Solution, 100 mg per mL for intrauterine use, is available in 100 mL and 250 mL multiple dose vials.
Abbreviated New Animal Drug Application
GENTAMICIN SULFATE- GENTAMICIN SULFATE SOLUTION ASPEN VETERINARY RESOURCES, LTD. ---------- GENTAMICIN SULFATE SOLUTION 100 MG/ML STERILE MULTIPLE DOSE VIAL NOT FOR USE IN HUMANS KEEP OUT OF REACH OF CHILDREN CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. APPROVED BY FDA UNDER ANADA # 200-395 DESCRIPTION Each mL of Gentamicin Sulfate Solution contains gentamicin sulfate veterinary equivalent to 100 mg gentamicin base; 2.4 mg sodium metabisulfite; 0.8 mg sodium sulfite, anhydrous; 0.1 mg edetate disodium; 10 mg benzyl alcohol as preservative; water for injection q.s. CHEMISTRY: GENTAMICIN IS A MIXTURE OF AMINGLYCOSIDE ANTIBIOTICS DERIVED FROM THE FERMENTATION OF_ MICROMONOSPORA PURPUREA_. GENTAMICIN SULFATE IS A MIXTURE OF SULFATE SALTS OF THE ANTIBIOTICS PRODUCED IN THIS FERMENTATION. THE SALTS ARE WEAKLY ACIDIC, FREELY SOLUBLE IN WATER, AND STABLE IN SOLUTION. ANTIBACTERIAL ACTIVITY:_ In Vitro_ antibacterial activity has shown that gentamicin is active against most gram-negative and gram-positive bacteria isolated from domestic animals. Gentamicin is active against _Pseudomonas aeruginosa_, indole-positive and - negative_ Proteus_ species, _Escherichia coli_,_ Klebsiella_ species, _Enterobacter _species, _Alcaligenes _species, _Staphylococcus _species, and _Streptococcus _species. PHARMACOLOGY: Studies in man indicate that recommended doses of gentamicin produce serum concentrations bactericidal for most bacteria sensitive to gentamicin within an hour after intramuscular injection; these concentrations last for 6 to 12 hours. Some 30% of the administered dose of gentamicin is bound by serum proteins and released as the drug is excreted. Gentamicin is excreted almost entirely by glomerular filtration. High concentrations of the active form are found in the urine. Fifty to 100% of the gentamicin injected can be recovered unchanged within 24 hours from the urine of patients with normal renal function. A small amount is excreted into the bile. TOXICITY STUDIES: No toxi Prečítajte si celý dokument