Krajina: Austrália
Jazyk: angličtina
Zdroj: Department of Health (Therapeutic Goods Administration)
escitalopram oxalate
Lupin Australia Pty Limited
escitalopram oxalate
Registered
1 ESCITALOPRAM-MPPL TABLETS Escitalopram oxalate (Lupin Australia Pty. Ltd.) CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet contains answers to some common questions about Escitalopram- MPPL Tablets. It does not contain all the information that is known about Escitalopram-MPPL Tablets. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risk of you using this medicine against the benefits he/she expects it will have for you. IF YOU HAVE ANY CONCERNS ABOUT USING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. 2 WHAT ESCITALOPRAM-MPPL TABLETS ARE USED FOR Escitalopram-MPPL Tablets are used to treat depression. It belongs to a group of medicines called selective serotonin reuptake inhibitors (SSRIs). They are thought to work by their actions on brain chemicals called amines which are involved in controlling mood. Depression is longer lasting or more severe than the "low moods" everyone has from time to time due to the stress of everyday life. It is thought to be caused by a chemical imbalance in parts of the brain. This imbalance affects your whole body and can cause emotional and physical symptoms such as feeling low in spirit, loss of interest in activities, being unable to enjoy life, poor appetite or overeating, disturbed sleep, often waking up early, loss of sex drive, lack of energy and feeling guilty over nothing. Escitalopram-MPPL Tablets correct this chemical imbalance and may help relieve the symptoms of depression. Escitalopram-MPPL Tablets may also be used to treat patients who may avoid and/or are fearful of social situations. Escitalopram-MPPL Tablets may also be used to treat patients who have excessive anxiety and worry. Escitalopram-MPPL Tablets may also be used to treat irrational fears or obsessional behaviour (obsessive-compulsive disorder). Obsessive-compulsive disorder involves having both obsessions and compulsions. Obsessions Prečítajte si celý dokument
ESCITALOPRAM-MPPL TABLETS (LUPIN AUSTRALIA PTY. LTD) NAME OF THE MEDICINE Escitalopram-MPPL Tablets 5 mg containing escitalopram (as oxalate) 5 mg, Escitalopram-MPPL Tablets 10 mg containing escitalopram (as oxalate) 10 mg, Escitalopram-MPPL Tablets 15 mg containing escitalopram (as oxalate) 15 mg and Escitalopram-MPPL Tablets 20 mg containing escitalopram (as oxalate) 20 mg ESCITALOPRAM OXALATE It is described chemically as S (+)-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroiso benzofuran-5-carbonitrile hydrogen oxalate. Escitalopram is the active enantiomer (S-enantiomer) of citalopram. Molecular formula: C 20 H 21 FN 2 O, C 2 H 2 O 4 Molecular Weight: 414.42 CAS: 219861-08-2 Chemical structure: DESCRIPTION Escitalopram oxalate is a fine white to yellow, crystalline material. Escitalopram oxalate is sparingly soluble in water, slightly soluble in acetone, soluble in ethanol and freely soluble in methanol. No polymorphic forms have been detected. EXCIPIENTS Microcrystalline cellulose, Croscarmellose sodium, , Colloidal silicon dioxide, Purified talc, Magnesium stearate and Opadry White Y-1-7000, ARTG no. 2731 (contains Hypromellose, Macrogol 400 and Titanium dioxide). _Escitalopram-MPPL tablet _ _Product Information _ _Lupin Australia Pty Ltd _ Page 2 of 40 PHARMACOLOGY PHARMACODYNAMICS: Biochemical and behavioural studies have shown that escitalopram is a potent inhibitor of serotonin (5-HT)-uptake (_in vitro _IC 50 2nM). The anti-depressant action of escitalopram is presumably linked to the potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibitory effect on the reuptake of 5- HT from the synaptic cleft. Escitalopram is a highly selective Serotonin Reuptake Inhibitor (SSRI). On the basis of _ in vitro _ studies, escitalopram had no, or minimal effect on noradrenaline (NA), dopamine (DA) and gamma aminobutyric acid (GABA) uptake. In contrast to many tricyclic anti-depressants and some of the SSRIs, escitalopram has no or very low affinity for a series of r Prečítajte si celý dokument