DOXYCYCLINE HYCLATE capsule

Krajina: Spojené štáty

Jazyk: angličtina

Zdroj: NLM (National Library of Medicine)

Aktívna zložka:

Doxycycline Hyclate (UNII: 19XTS3T51U) (Doxycycline Anhydrous - UNII:334895S862)

Dostupné z:

Dispensing Solutions, Inc.

INN (Medzinárodný Name):

Doxycycline Hyclate

Zloženie:

Doxycycline Anhydrous 50 mg

Spôsob podávania:

ORAL

Typ predpisu:

PRESCRIPTION DRUG

Terapeutické indikácie:

To reduce the development of drug-resistant bacteria and maintain effectiveness of doxycycline hyclate and other antibacterial drugs, doxycycline hyclate should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Treatment: Doxycycline is indicated for the treatment of the following infections: - Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae. - Respiratory tract infections caused by Mycoplasma pneumoniae . - Lymphogranuloma venereum caused by Chlamydia trachomatis . - Psittacosis (ornithosis) caused by Chlamydia psittaci . - Trachoma caused by Chlamydia trachomatis , although the infectious agent is not a

Prehľad produktov:

HOW SUPPLIED: Doxycycline hyclate capsules and tablets are available as follows: Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature] DISPENSE IN TIGHT, LIGHT-RESISTANT CONTAINER.

Stav Autorizácia:

Abbreviated New Drug Application

Súhrn charakteristických

DOXYCYCLINE HYCLATE- DOXYCYCLINE HYCLATE CAPSULE
DISPENSING SOLUTIONS, INC.
----------
DOXYCYCLINE HYCLATE CAPSULES USP
50 MG AND 100 MG
DOXYCYCLINE HYCLATE TABLETS USP
100 MG
RX ONLY
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of doxycycline
hyclate and other antibacterial drugs, doxycycline hyclate should be
used only to treat or prevent
infections that are proven or strongly suspected to be caused by
bacteria.
DESCRIPTION
Doxycycline is a broad-spectrum antibiotic synthetically derived from
oxytetracycline, and is available
as doxycycline hyclate (doxycycline hydrochloride hemiethanolate
hemihydrate) capsules and tablets
for oral administration. The chemical designation of this light-yellow
crystalline powder is alpha-6-
deoxy-5-oxytetracycline. Doxycycline has a high degree of lipoid
solubility and a low affinity for
calcium binding. It is highly stable in normal human serum.
Doxycycline will not degrade into an
epianhydro form. Doxycycline hyclate has the following structural
formula:
(C
H
N O •HCL)
•C H O•H O M.W. 1025.89
Each capsule for oral administration contains 50 mg or 100 mg
doxycycline hyclate, equivalent to 50
mg or 100 mg doxycycline (anhydrous). Inactive ingredients for
capsules are: anhydrous lactose,
croscarmellose sodium, D&C Red #28, FD&C Blue #1, gelatin, magnesium
stearate, microcrystalline
cellulose, and titanium dioxide. Each tablet for oral administration
contains 100 mg doxycycline hyclate,
equivalent to 100 mg doxycycline. Inactive ingredients for tablets
are: anhydrous lactose, carnauba wax,
croscarmellose sodium, D&C Yellow #10 aluminum lake, FD&C Red #40
aluminum lake,
hypromellose, magnesium stearate, microcrystalline cellulose,
polyethylene glycol, polysorbate 80,
and titanium dioxide.
CLINICAL PHARMACOLOGY
Tetracyclines are readily absorbed and are bound to plasma proteins in
varying degree. They are
concentrated by the liver in the bile, and excreted in the urine and
feces at high concentrations and in a
biologically active form. Do