DEXASONE INJECTION 5MG (1ML AMP)

Krajina: Malajzia

Jazyk: angličtina

Zdroj: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktívna zložka:

DEXAMETHASONE SODIUM PHOSPHATE

Dostupné z:

ATLANTIC LABORATORIES (M) SDN. BHD.

INN (Medzinárodný Name):

DEXAMETHASONE SODIUM PHOSPHATE

Počet v balení:

1ml x 50 Ampoules

Výrobca:

ATLANTIC LABORATORIES CORPORATION LTD

Súhrn charakteristických

NAME AND STRENGTH OF ACTIVE SUBSTANCE(S)
Dexamethasone Injection 5mg/ml
PRESERVATIVE:
Phenol 5 mg/ml.
PRODUCT DESCRIPTION
Dexasone
Injection
is
a
clear
colorless
sterile
solution
of
Dexamethasone phosphate sodium eq. to Dexamethasone fill in
glass ampoule.
PHARMACODYNAMICS:
The glucocorticoid steroids actions are mainly anti-inflammatory,
anti-allergic and anti-rheumatic, in conditions such as asthma and
rheumatoid arthritis. It appears that a measure of a corticosteroids
potency as glucocorticoid is the degree of inhibition of
corticotrophin
secretion it produces. Dexamethasone has immunosuppressant
properties and can be administered to reduce immune response
after organ transplant.
PHAMACOKINETICS:
Dexasone Injection has rapid onset of action but of short duration.
In the circulation, dexamethasone is bound to the plasma protein,
but to a lesser extent than for other corticosteroids, mainly to
globulin and less to albumin. The corticoid-binding globulin has high
affinity low binding capacity, while the albumin had low affinity but
large
binding
capacity.
Only
unbound
dexamethasone
has
pharmacological effects or is metabolized. Corticosteroids diffuses
into tissue fluids and cerebrospinal fluids but Trans placental
diffusion
in
significant
amounts
had
not
been
demonstrated.
Corticosteroids
are
metabolized
in
the
liver
and
kidney
and
excreted in the urine. The slower metabolism and lower protein
binding affinity of dexamethasone may account for its increased
potency compared with the natural corticosteroids. The biological
half-life in plasma of dexamethasone is about 190 minutes.
INDICATION:
Severe
allergic
reactions,
anaphylactic
due
to
drugs,
acute
bronchial
asthma,
transfusion
reactions,
Steven-Johnson
syndrome, acute dermatosis and laryngeal edema. Thyroid crisis
and acute thyroiditis.
Adrenocortical insufficiency. Management of the symptoms and
symptomatic relief of rheumatoid arthritis, rheumatic fever, status
asthmaticus, other inflammatory conditions and ulcerative colitis. It
is useful in the treatment