AA-Lovastatin Tablet 20mg

Krajina: Malajzia

Jazyk: angličtina

Zdroj: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktívna zložka:

LOVASTATIN

Dostupné z:

PHARMAFORTE (MALAYSIA) SDN. BHD.

INN (Medzinárodný Name):

LOVASTATIN

Počet v balení:

30 Tablet Tablets; 500 Tablet Tablets

Výrobca:

APOTEX INC

Príbalový leták

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
A
A
-LOVASTATIN 20MG TAB
Lovastatin
Page 1
WHAT IS IN THIS LEAFLET
1.
What is AA-Lovastatin is
used for
2.
How AA-Lovastatin works
3.
Before you AA-Lovastatin
4.
How to use AA-Lovastatin
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of AA-
Lovastatin
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
This leaflet answers some of the
common
questions
people
ask
about
AA-LOVASTATIN.
It
does
not
contain
all
the
information that is known about
AA-LOVASTATIN.
It
does
not
take
the
place
of
talking
to
your
doctor
or
pharmacist.
All
medicines
have
risks
and
benefits.
Your
doctor
will
have
weighed the risks of you taking
AA-LOVASTATIN against the
benefits they expect it will have
for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP
THIS
LEAFLET
WITH
THE
MEDICINE.
You may need to read it again.
WHAT IS A
A
-LOVASTATIN IS USED
FOR
AA-LOVASTATIN is one of a
class of medicines known as Lipid
Metabolism Regulators.
When
it
is
necessary
to
lower
cholesterol, physicians usually try
to control the condition, known as
hypercholesterolemia,
with
a
carefully
supervised
diet.
Also
your
physician
may recommend
other measures such as exercise
and weight control.
Medicines
like
this
one
are
prescribed along with, and not as
a substitute for, a special diet and
other measures.
Lovastatin is used
to lower
the
levels of cholesterol (particularly
Low Density Lipoprotein (LDL)
cholesterol) and other fats in the
blood.
This
may
help
prevent
heart
disease
if
caused
by
cholesterol
clogging
the
blood
vessels or slow the progression of
atherosclerosis (hardening) of the
arteries
that
nourish
your
heart,
so-called
coronary
heart
disease
(CHD).
HOW A
A
-LOVASTATIN WORKS AA-
LOVASTATIN
inhibits
an
enzyme that is necessary for the
body to make cholesterol. In this
way, less cholesterol is produced
in the liver.
BEFORE YOU USE A
A
-LOVASTATIN _-_
_When you must not use it_
Tell your physician if
�

Súhrn charakteristických

AA-LOVASTATIN
LOVASTATIN TABLETS USP 20MG
LIPID METABOLISM REGULATOR
PHARMACOLOGY:
Lovastatin
is
a
cholesterol-lowering
agent
isolated
from
a
strain
of
Coniothyrium
fuckelli.
After
oral
ingestion,
lovastatin,
which
is
an
inactive
lactone,
is
hydrolyzed
to
the
corresponding
ß
-hydroxyacid form. This principal metabolite is a specific inhibitor
of 3-hydroxy-3-
methyl-glutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes
the conversion of HMG-CoA
to mevalonate, which is an early and rate-limiting step in the
biosynthesis of cholesterol.
Lovastatin
reduces cholesterol production by the liver and induces some changes
in cholesterol transport and
disposition in the blood and tissues. The mechanism(s) of this effect
is believed to involve both
reduction of the synthesis of Low Density Lipoprotein (LDL), and an
increase in LDL catabolism as a
result of induction of the hepatic LDL receptors.
Human Pharmacology: Lovastatin has been shown to reduce both normal
and elevated LDL-cholesterol
concentrations. THE EFFECT OF LOVASTATIN-INDUCED CHANGES IN
LIPOPROTEIN LEVELS, INCLUDING REDUCTION OF
SERUM CHOLESTEROL, ON CARDIOVASCULAR MORBIDITY OR MORTALITY, AS WELL
AS ON TOTAL MORTALITY, HAS NOT
BEEN ESTABLISHED.
LDL is formed from VLDL and is catabolized predominantly by the high
affinity LDL receptor. The
mechanism of the LDL-lowering effect of lovastatin may involve both
reduction of VLDL-cholesterol
concentration, and induction of the LDL receptor leading to reduced
production and/or increased
catabolism of LDL-cholesterol.
Apolipoprotein B also falls substantially during treatment with
lovastatin. Since each LDL particle
contains
one
molecule
or
apolipoprotein
B,
and
since
little
apolipoprotein
B
is
found
in
other
lipoproteins, this strongly suggests that lovastatin does not merely
cause cholesterol to be lost from
LDL,
but
also
reduces
the
concentration
of
circulating
LDL
particles.
However,
a
change
in
the
composition
of
the
LDL
particle
(lipid/protein
ratio)
cannot
be
excluded
during
treatment
with
lovastatin. In