TRIOSTAT® brand of liothyronine sodium injection (T3 )

Страна: Соединенные Штаты

Язык: английский

Источник: NLM (National Library of Medicine)

Активный ингредиент:

LIOTHYRONINE SODIUM (UNII: GCA9VV7D2N) (LIOTHYRONINE - UNII:06LU7C9H1V)

Доступна с:

Par Pharmaceutical, Inc.

ИНН (Международная Имя):

LIOTHYRONINE SODIUM

состав:

LIOTHYRONINE 10 ug in 1 mL

Администрация маршрут:

INTRAVENOUS

Тип рецепта:

PRESCRIPTION DRUG

Терапевтические показания :

Triostat (liothyronine sodium injection) (T3 ) is indicated in the treatment of myxedema coma/precoma. Triostat can be used in patients allergic to desiccated thyroid or thyroid extract derived from pork or beef. Thyroid hormone preparations are generally contraindicated in patients with diagnosed but as yet uncorrected adrenal cortical insufficiency or untreated thyrotoxicosis. Thyroid hormone preparations are also generally contraindicated in patients with hypersensitivity to any of the active or extraneous constituents of these preparations; however, there is no well-documented evidence in the literature of true allergic or idiosyncratic reactions to thyroid hormone. Concomitant use of Triostat and artificial rewarming of patients is contraindicated. (See PRECAUTIONS .)

Обзор продуктов:

The 1 mL vial at a concentration of 10 mcg/mL is available as follow: NDC 42023-120-01-Single-Use Vial- Pack of 1 NDC 42023-120-06-Single-Use Vials- Pack of 6 Store between 2° and 8°C (36° and 46°F).

Статус Авторизация:

New Drug Application

Характеристики продукта

TRIOSTAT- LIOTHYRONINE SODIUM INJECTION
PAR PHARMACEUTICAL, INC.
----------
TRIOSTAT
BRAND OF LIOTHYRONINE SODIUM INJECTION (T )
PRESCRIBING INFORMATION
DESCRIPTION
Thyroid hormone drugs are natural or synthetic preparations containing
tetraiodothyronine (T ,
levothyroxine) sodium or triiodothyronine (T , liothyronine) sodium or
both. T and T are produced in
the human thyroid gland by the iodination and coupling of the amino
acid tyrosine. T contains four
iodine atoms and is formed by the coupling of two molecules of
diiodotyrosine (DIT). T contains three
atoms of iodine and is formed by the coupling of one molecule of DIT
with one molecule of
monoiodotyrosine (MIT). Both hormones are stored in the thyroid
colloid as thyroglobulin and released
into the circulation. The major source of T has been shown to be
peripheral deiodination of T . T is
bound less firmly than T in the serum, enters peripheral tissues more
readily, and binds to specific
nuclear receptor(s) to initiate hormonal, metabolic effects. T is the
prohormone which is deiodinated
to T for hormone activity.
Thyroid hormone preparations belong to two categories: (1) natural
hormonal preparations derived from
animal thyroid, and (2) synthetic preparations. Natural preparations
include desiccated thyroid and
thyroglobulin. Desiccated thyroid is derived from domesticated animals
that are used for food by man
(either beef or hog thyroid), and thyroglobulin is derived from
thyroid glands of the hog.
Triostat (liothyronine sodium injection) (T ) contains liothyronine
(L-triiodothyronine or L-T ), a
synthetic form of a natural thyroid hormone, as the sodium salt.
The structural and empirical formulas and molecular weight of
liothyronine sodium are given below.
L-Tyrosine, 0-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt
In euthyroid patients, 25 mcg of liothyronine is equivalent to
approximately 1 grain of desiccated
thyroid or thyroglobulin and 0.1 mg of L-thyroxine.
Each mL of _Triostat_ in amber-glass vials contains, in sterile
non-pyrogenic aqueous