Страна: Израиль
Язык: английский
Источник: Ministry of Health
THIOPENTAL SODIUM
PHARMALOGIC LTD
N05CA19
POWDER FOR SOLUTION FOR INJECTION
THIOPENTAL SODIUM 1 G
I.V
Required
PANPHARMA LABORATORIES, FRANCE
THIOPENTAL
THIOPENTAL
Anaesthesia of short duration without assisted ventilation. - Initiation of general Anaesthesia with OR without assisted ventilation. - It is also used as an adjunct For Control of convulsive disorders of various aetiology including those CAUSED BY local anaesthetics.
2010-05-31
THIOPENTAL INJECTION B.P. COMPOSITION Powder for Injection: Vials containing sterile powder of thiopental sodium 0.5 gm for extemporaneous preparation of 2.5% solution. Vials containing sterile powder of thiopental sodium 1 gm for extemporaneous preparation of 5% solution. USES Administered intravenously, Thiopental Injection B.P. produces general anaesthesia of short duration. Thiopental Injection B.P. is indicated for the induction of general anaesthesia of short duration; it is also used as an adjunct for control of convulsive disorders of various aetiology, including those caused by local anaesthetics. Other Information: Although bound to plasma proteins, it rapidly crosses the blood-brain barrier and reaches maximum concentration in the brain within 30 seconds of injection. It is slowly metabolised by the liver. Only a small proportion of the active drug is excreted in the urine. PHARMACOTHERAPEUTIC GROUP Barbiturates, Plain ATC Code: N01AF DOSAGE AND METHOD OF ADMINISTRATION Thiopental Injection B.P. is administered intravenously as a 2.5% w/v (500 mg in 20 ml) solution. On occasion it may be administered as a 5% w/v solution (500 mg in 10 ml). The obtained solution for intravenous injection should be used immediately; any remaining portion of the content should be discarded. Thiopental sodium injection is usually administered as a 2.5% solution. The content of the vial should be dissolved in 20 ml Water for injection. USE IN ANAESTHESIA Normal dosage for the induction of anaesthesia is 100 mg to 150 mg injected intravenously over 10 to 15 seconds. If necessary a repeated dose of 100 mg to 150 mg may be administered after one minute. No fixed dosage recommendations for the intravenous injection can be given, since the dosage should be carefully adjusted according to the patient's response. Factors such as age, sex and weight of the patient should be taken into consideration. Thiopental sodium reaches effective concentrations in the brain within 30 seconds and anaesthesia is normally produced within one minu Прочитать полный документ