Соединенные Штаты - английский - NLM (National Library of Medicine)

indiana oxygen company inc - oxygen (unii: s88tt14065) (oxygen - unii:s88tt14065) - oxygen 99 l in 100 l

Соединенные Штаты - английский - NLM (National Library of Medicine)

indiana oxygen company inc - nitrogen (unii: n762921k75) (nitrogen - unii:n762921k75) - nitrogen 99 l in 100 l

Европейский союз - английский - EMA (European Medicines Agency)

merck sharp & dohme b.v.  - recombinant vesicular stomatitis virus (strain indiana) with a deletion of the envelope glycoprotein, replaced with the zaire ebolavirus (strain kikwit 1995) surface glycoprotein - hemorrhagic fever, ebola - vaccines - ervebo is indicated for active immunization of individuals 1 year of age or older to protect against ebola virus disease (evd) caused by zaire ebola virus.the use of ervebo should be in accordance with official recommendations.

Соединенные Штаты - английский - NLM (National Library of Medicine)

remedyrepack inc. - clonazepam (unii: 5pe9fde8gb) (clonazepam - unii:5pe9fde8gb) - seizure disorders: clonazepam tablets are useful alone or as an adjunct in the treatment of the lennox- gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. in patients with absence seizures (petit mal) who have failed to respond to succinimides, clonazepam tablets may be useful. some loss of effect may occur during the course of clonazepam treatment (see precautions: loss of effect). panic disorder: clonazepam tablets are indicated for the treatment of panic disorder, with or without agoraphobia, as defined in dsm-v. panic disorder is characterized by the occurrence of unexpected panic attacks and associated concern about having additional attacks, worry about the implications or consequences of the attacks, and/or a significant change in behavior related to the attacks. the efficacy of clonazepam tablets was established in two 6- to 9-week trials  in panic disorder patients whose diagnoses corresponded to the dsm-lilr category of panic disorder (see clinical pharmacology: clinical trials). panic disorder (dsm-v) is characterized by recurrent unexpected panic attacks, i.e., a discrete  period of intense fear or discomfort in which four (or more) of the following symptoms develop abruptly and reach a peak within 10 minutes: (1) palpitations, pounding heart or accelerated heart rate; (2) sweating; (3) trembling or shaking; (4) sensations of shortness of breath or smothering; (5) feeling of choking; (6) chest pain or discomfort; (7) nausea or abdominal distress; (8) feeling dizzy, unsteady, lightheaded or faint; (9) derealization (feelings of unreality) or depersonalization (being detached from oneself); (10) fear of losing control; (11) fear of dying; (12) paresthesias (numbness  or tingling  sensations); (13) chills or hot flushes. the effectiveness of clonazepam tablets in long-term use, that is, for more than 9 weeks, has not been systematically studied in controlled clinical trials. the physician who elects to use clonazepam tablets for extended periods should periodically reevaluate the long- term usefulness of the drug for the individual patient (see dosage and administration). clonazepam tablets are contraindicated in patients with the following conditions: - history of sensitivity to benzodiazepines - clinical or biochemical evidence of significant liver disease - acute narrow angle glaucoma (it may be used in patients with open angle glaucoma who are receiving appropriate therapy). controlled substance class: clonazepam tablets contain clonazepam, a schedule iv controlled substance. abuse: clonazepam tablet is a benzodiazepine and a cns depressant with a potential for abuse and addiction. abuse is the intentional, non-therapeutic use of a drug, even once, for its desirable psychological or physiological effects. misuse is the intentional use, for therapeutic purposes, of a drug by an individual in a way other than prescribed by a health care provider or for whom it was not prescribed. drug addiction is a cluster of behavioral, cognitive, and physiological phenomena that may include a strong desire to take the drug, difficulties in controlling drug use (e.g., continuing drug use despite harmful consequences, giving a higher priority to  drug  use  than other  activities  and obligations), and possible tolerance or physical dependence. even taking benzodiazepines as prescribed may put patients at risk for abuse and misuse of their medication. abuse and misuse  may  lead to addiction. abuse and misuse of benzodiazepines often (but not always) involve the use of doses greater than the maximum recommended dosage and commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes, including respiratory depression, overdose, or death. benzodiazepines are often sought by individuals who abuse drugs and other substances, and by individuals with addictive disorders (see warnings: abuse, misuse, and addiction ). the following adverse reactions have occurred with benzodiazepine abuse  and/or  misuse: abdominal pain, amnesia, anorexia, anxiety, aggression, ataxia, blurred vision, confusion, depression, disinhibition, disorientation, dizziness, euphoria, impaired concentration and memory, indigestion, irritability, muscle pain, slurred speech, tremors, and vertigo. the following severe adverse reactions have occurred with benzodiazepine abuse and/or  misuse: delirium, paranoia, suicidal ideation and behavior, seizures, coma, breathing  difficulty, and  death. death is more often associated with polysubstance use  (especially benzodiazepines  with other  cns depressants such as opioids and alcohol) . dependence: physical dependence clonazepam tablets may produce physical dependence from continued therapy. physical dependence is a state that develops as a result of physiological adaptation in response to repeated drug use, manifested by withdrawal signs and symptoms after abrupt discontinuation or a significant dose reduction of a drug. abrupt discontinuation or rapid dosage reduction of benzodiazepines or administration of flumazenil, a benzodiazepine antagonist, may precipitate acute withdrawal reactions, including seizures, which can be life-threatening. patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or  rapid dosage reduction include those who take higher dosages (i.e., higher and/or more frequent doses) and those who have had longer durations of use (see warnings: dependence and withdrawal reactions) to reduce the risk of withdrawal reactions, use a gradual taper to discontinue clonazepam tablets or reduce the dosage (see dosage and administration: discontinuation or dosage reduction of clonazepam tablets and warnings: dependence and withdrawal reactions). acute withdrawal signs and symptoms acute withdrawal signs and symptoms associated with benzodiazepines have included abnormal involuntary movements, anxiety, blurred vision, depersonalization, depression, derealization, dizziness, fatigue, gastrointestinal adverse reactions (e.g., nausea, vomiting, diarrhea, weight loss, decreased appetite), headache, hyperacusis, hypertension, irritability, insomnia, memory impairment, muscle  pain and stiffness, panic attacks, photophobia, restlessness, tachycardia, and tremor. more severe acute withdrawal signs and symptoms, including life-threatening reactions, have  included catatonia, convulsions, delirium tremens, depression, hallucinations, mania, psychosis, seizures and suicidality. protracted withdrawal syndrome protracted withdrawal syndrome associated with benzodiazepines is characterized by anxiety, cognitive impairment, depression, insomnia, formication, motor symptoms (e.g.,  weakness,  tremor,  muscle twitches), paresthesia, and tinnitus that persists beyond 4 to  6  weeks after initial benzodiazepine withdrawal. protracted withdrawal symptoms may last weeks to more  than 12 months . as  a result, there may be difficulty in differentiating withdrawal symptoms from potential re-emergence or continuation of symptoms for which the benzodiazepine was being used. tolerance tolerance to clonazepam tablets  may  develop  from continued  therapy.  tolerance is a physiological state characterized by a reduced response to  a drug  after repeated administration (i.e., a higher dose of a drug is required to produce the same effect that was once obtained at a lower dose). tolerance to the therapeutic effect of clonazepam tablets may  develop; however, little tolerance develops to the amnestic reactions and other cognitive impairments caused by benzodiazepines. following the short-term treatment of patients with panic disorder in studies 1 and 2 (see clinical pharmacology: clinical trials) , patients were gradually withdrawn during a 7-week downward- titration (discontinuance) period. overall, the discontinuance period was associated with good tolerability and a very modest clinical deterioration, without evidence of a significant rebound phenomenon. however, there are not sufficient data from adequate and well-controlled long-term clonazepam studies in patients with panic disorder to accurately estimate the risks of withdrawal symptoms and dependence that may be associated with such use. what is the most important information i should know about clonazepam tablets? - clonazepam tablet is a benzodiazepine medicine. taking benzodiazepines with opioid medicines, alcohol, or other central nervous system (cns) depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression), coma, and death. get emergency help right away if any of the following happens: - shallow or slowed breathing - breathing stops (which may lead to the heart stopping) - excessive sleepiness (sedation) do not drive or operate heavy machinery until you know how taking clonazepam tablets with opioids affects you. - risk of abuse, misuse, and addiction . there is a risk of abuse, misuse, and addiction with benzodiazepines, including clonazepam tablet which can lead to overdose and serious side effects including coma and death. - serious side effects including coma and death have happened in people who have abused or misused benzodiazepines, including clonazepam tablets. these serious side effects may also include delirium, paranoia, suicidal thoughts or actions, seizures, and difficulty breathing. call your healthcare provider or go to the nearest hospital emergency room right away if you get any of these serious side effects. - you can develop an addiction even if you take clonazepam tablets as prescribed by your healthcare provider. - take clonazepam tablets exactly as your healthcare provider prescribed. - do not share your clonazepam tablets with other people. - keep clonazepam tablets in a safe place and away from children. - physical dependence and withdrawal reactions. clonazepam tablets can cause physical dependence and withdrawal reactions. do not suddenly stop taking clonazepam tablets . stopping clonazepam tablets suddenly can cause serious and life-threatening side effects, including, unusual movements, responses, or expressions, seizures, sudden and severe mental or nervous system changes, depression, seeing or hearing things that others do not see or hear, an extreme increase in activity or talking, losing touch with reality, and suicidal thoughts or actions. call your healthcare provider or go to the nearest hospital emergency room right away if you get any of these symptoms. some people who suddenly stop benzodiazepines have symptoms that can last for several weeks to more than 12 months, including, anxiety, trouble remembering, learning, or concentrating, depression, problems sleeping, feeling like insects are crawling under your skin, weakness, shaking, muscle twitching, burning or prickling feeling in your hands, arms, legs or feet, and ringing in your ears. physical dependence is not the same as drug addiction. your healthcare provider can tell you more about the differences between physical dependence and drug addiction. do not take more clonazepam tablets than prescribed or take clonazepam tablets for longer than prescribed. - do not suddenly stop taking clonazepam tablets . stopping clonazepam tablets suddenly can cause serious and life-threatening side effects, including, unusual movements, responses, or expressions, seizures, sudden and severe mental or nervous system changes, depression, seeing or hearing things that others do not see or hear, an extreme increase in activity or talking, losing touch with reality, and suicidal thoughts or actions. call your healthcare provider or go to the nearest hospital emergency room right away if you get any of these symptoms. - some people who suddenly stop benzodiazepines have symptoms that can last for several weeks to more than 12 months, including, anxiety, trouble remembering, learning, or concentrating, depression, problems sleeping, feeling like insects are crawling under your skin, weakness, shaking, muscle twitching, burning or prickling feeling in your hands, arms, legs or feet, and ringing in your ears. - physical dependence is not the same as drug addiction. your healthcare provider can tell you more about the differences between physical dependence and drug addiction. - do not take more clonazepam tablets than prescribed or take clonazepam tablets for longer than prescribed. - clonazepam tablets can make you sleepy or dizzy and can slow your thinking and motor skills. this may get better over time. do not drive, operate heavy machinery, or do other dangerous activities until you know how clonazepam tablets affects you. clonazepam tablets may cause problems with your coordination, especially when you are walking or picking things up. - do not drive, operate heavy machinery, or do other dangerous activities until you know how clonazepam tablets affects you. - clonazepam tablets may cause problems with your coordination, especially when you are walking or picking things up. - do not drink alcohol or take other drugs that may make you sleepy or dizzy while taking clonazepam tablets until you talk to your healthcare provider. when taken with alcohol or drugs that cause sleepiness or dizziness, clonazepam tablets may make your sleepiness or dizziness worse. - like other antiepileptic drugs, clonazepam tablets may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. call your healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you: - thoughts about suicide or dying ◦ attempt to commit suicide ◦ new or worse depression - new or worse anxiety ◦ feeling agitated or restless ◦ panic attacks - trouble sleeping (insomnia) ◦ new or worse irritability ◦ acting aggressive, being angry, or violent - acting on dangerous impulses ◦ an extreme increase in activity and talking (mania) ◦ other unusual changes in behavior or mood how can i watch for early symptoms of suicidal thoughts and actions? - pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. - keep all follow-up visits with your healthcare provider as scheduled. call your healthcare provider between visits as needed, especially if you are worried about symptoms. suicidal thoughts or actions can be caused by things other than medicines. if you have suicidal thoughts or actions, your healthcare provider may check for other causes. do not stop clonazepam tablets without first talking to a healthcare provider. - stopping clonazepam tablets suddenly can cause serious problems. stopping clonazepam tablets - suddenly can cause seizures that will not stop (status epilepticus). what are clonazepam tablets? - clonazepam tablets are prescription medicine used alone or with other medicines to treat: certain types of seizure disorders (epilepsy) in adults and children panic disorder with or without fear of open spaces (agoraphobia) in adults - certain types of seizure disorders (epilepsy) in adults and children - panic disorder with or without fear of open spaces (agoraphobia) in adults clonazepam tablet is a federally controlled substance (c-iv) because it contains clonazepam that can be abused or lead to dependence. keep clonazepam tablets in a safe place to prevent misuse and abuse. selling or giving away clonazepam tablets may harm others, and is against the law. tell your healthcare provider if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs. it is not known if clonazepam tablets are safe or effective in treating panic disorder in children younger than 18 years old. who should not take clonazepam tablets? do not take clonazepam tablets if you: - are allergic to benzodiazepines - have significant liver disease - have an eye disease called acute narrow angle glaucoma ask your healthcare provider if you are not sure if you have any of the problems listed above. before you take clonazepam tablets, tell your healthcare provider if you: - have liver or kidney problems - have lung problems (respiratory disease) - have or have had depression, mood problems, or suicidal thoughts or behavior - have any other medical problems - are pregnant or plan to become pregnant. it is not known if clonazepam tablets can harm your unborn baby. tell your healthcare provider right away if you become pregnant while taking clonazepam tablets. you and your healthcare provider will decide if you should take clonazepam tablets while you are pregnant. - studies in pregnant animals have shown harmful effects of benzodiazepine medications (including the active ingredient in clonazepam tablets) on the developing fetus. - children born to mothers receiving benzodiazepine medications (including clonazepam tablets) late in pregnancy may be at some risk of experiencing breathing problems, feeding problems, hypothermia, and withdrawal symptoms. - if you become pregnant while taking clonazepam tablets, talk to your healthcare provider about registering with the north american antiepileptic drug pregnancy registry. you can register by calling 1-888-233-2334. the purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy - are breastfeeding or plan to breastfeed. clonazepam can pass into breast milk. you and your healthcare provider should decide how you will feed your baby while you take clonazepam tablets. tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. taking clonazepam tablets with certain other medicines can cause side effects or affect how well clonazepam tablets or the other medicines work. do not start or stop other medicines without talking to your healthcare provider. how should i take clonazepam tablets? - take clonazepam tablets exactly as your healthcare provider tells you. if you take clonazepam tablets for seizures, your healthcare provider may change the dose until you are taking the right amount of medicine to control your symptoms. - clonazepam is available as a tablet. - do not stop taking clonazepam tablets without first talking to your healthcare provider. stopping clonazepam tablets suddenly can cause serious problems. - clonazepam tablets should be taken with water and swallowed whole. - if you take too much clonazepam tablets, call your healthcare provider or local poison control center right away. what should i avoid while taking clonazepam tablets? - clonazepam tablets can slow your thinking and motor skills. do not drive, operate heavy machinery, or do other dangerous activities until you know how clonazepam tablets affects you. - do not drink alcohol or take other medicines that may make you sleepy or dizzy while taking clonazepam tablets until you talk to your healthcare provider. when taken with alcohol or medicines that cause sleepiness or dizziness, clonazepam tablets may make your sleepiness or dizziness much worse. what are the possible side effects of clonazepam tablets? see “what is the most important information i should know about clonazepam tablets?” clonazepam tablets can also make your seizures happen more often or make them worse. call your healthcare provider right away if your seizures get worse while taking clonazepam tablets. the most common side effects of clonazepam tablets include: - drowsiness • dizziness • fatigue - problems with walking and coordination • depression • problems with memory these are not all the possible side effects of clonazepam tablets. call your doctor for medical advice about side effects. you may report side effects to fda at 1-800-fda-1088 or contact advagen pharma ltd, at 866-488-0312. how should i store clonazepam tablets? - store clonazepam tablets at 20°c to 25°c (68°f -77°f) [see usp controlled room temperature]. - keep clonazepam tablets and all medicines out of the reach of children. general information about the safe and effective use of clonazepam tablets. medicines are sometimes prescribed for purposes other than those listed in a medication guide. do not use clonazepam tablets for a condition for which it was not prescribed. do not give clonazepam tablets to other people, even if they have the same symptoms that you have. it may harm them. you can ask your pharmacist or healthcare provider for information about clonazepam tablets that is written for health professionals. for more information, contact advagen pharma ltd, at 866-488-0312. what are the ingredients in clonazepam tablets? active ingredient: clonazepam inactive ingredients: - 0.5 mg tablets contain lactose monohydrate, polyethylene glycol, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, fd & c yellow 6 al lake, d & c yellow 10 al lake - 1 mg tablets contain lactose monohydrate, polyethylene glycol, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, fd & c blue 1 al lake and fd & c blue 2 al lake - 2 mg tablets contain lactose monohydrate, polyethylene glycol, microcrystalline cellulose, croscarmellose sodium and magnesium stearate this medication guide has been approved by the u.s. food and drug administration. repackaged by / distributed by: remedyrepack inc. 625 kolter drive, indiana, pa 15701 (724) 465-8762

Соединенные Штаты - английский - NLM (National Library of Medicine)

remedyrepack inc. - clonazepam (unii: 5pe9fde8gb) (clonazepam - unii:5pe9fde8gb) - seizure disorders: clonazepam tablets are useful alone or as an adjunct in the treatment of the lennox- gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. in patients with absence seizures (petit mal) who have failed to respond to succinimides, clonazepam tablets may be useful. some loss of effect may occur during the course of clonazepam treatment (see precautions: loss of effect). panic disorder: clonazepam tablets are indicated for the treatment of panic disorder, with or without agoraphobia, as defined in dsm-v. panic disorder is characterized by the occurrence of unexpected panic attacks and associated concern about having additional attacks, worry about the implications or consequences of the attacks, and/or a significant change in behavior related to the attacks. the efficacy of clonazepam tablets was established in two 6- to 9-week trials  in panic disorder patients whose diagnoses corresponded to the dsm-lilr category of panic disorder (see clinical pharmacology: clinical trials). panic disorder (dsm-v) is characterized by recurrent unexpected panic attacks, i.e., a discrete  period of intense fear or discomfort in which four (or more) of the following symptoms develop abruptly and reach a peak within 10 minutes: (1) palpitations, pounding heart or accelerated heart rate; (2) sweating; (3) trembling or shaking; (4) sensations of shortness of breath or smothering; (5) feeling of choking; (6) chest pain or discomfort; (7) nausea or abdominal distress; (8) feeling dizzy, unsteady, lightheaded or faint; (9) derealization (feelings of unreality) or depersonalization (being detached from oneself); (10) fear of losing control; (11) fear of dying; (12) paresthesias (numbness  or tingling  sensations); (13) chills or hot flushes. the effectiveness of clonazepam tablets in long-term use, that is, for more than 9 weeks, has not been systematically studied in controlled clinical trials. the physician who elects to use clonazepam tablets for extended periods should periodically reevaluate the long- term usefulness of the drug for the individual patient (see dosage and administration). clonazepam tablets are contraindicated in patients with the following conditions: - history of sensitivity to benzodiazepines - clinical or biochemical evidence of significant liver disease - acute narrow angle glaucoma (it may be used in patients with open angle glaucoma who are receiving appropriate therapy). controlled substance class: clonazepam tablets contain clonazepam, a schedule iv controlled substance. abuse: clonazepam tablet is a benzodiazepine and a cns depressant with a potential for abuse and addiction. abuse is the intentional, non-therapeutic use of a drug, even once, for its desirable psychological or physiological effects. misuse is the intentional use, for therapeutic purposes, of a drug by an individual in a way other than prescribed by a health care provider or for whom it was not prescribed. drug addiction is a cluster of behavioral, cognitive, and physiological phenomena that may include a strong desire to take the drug, difficulties in controlling drug use (e.g., continuing drug use despite harmful consequences, giving a higher priority to  drug  use  than other  activities  and obligations), and possible tolerance or physical dependence. even taking benzodiazepines as prescribed may put patients at risk for abuse and misuse of their medication. abuse and misuse  may  lead to addiction. abuse and misuse of benzodiazepines often (but not always) involve the use of doses greater than the maximum recommended dosage and commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes, including respiratory depression, overdose, or death. benzodiazepines are often sought by individuals who abuse drugs and other substances, and by individuals with addictive disorders (see warnings: abuse, misuse, and addiction ). the following adverse reactions have occurred with benzodiazepine abuse  and/or  misuse: abdominal pain, amnesia, anorexia, anxiety, aggression, ataxia, blurred vision, confusion, depression, disinhibition, disorientation, dizziness, euphoria, impaired concentration and memory, indigestion, irritability, muscle pain, slurred speech, tremors, and vertigo. the following severe adverse reactions have occurred with benzodiazepine abuse and/or  misuse: delirium, paranoia, suicidal ideation and behavior, seizures, coma, breathing  difficulty, and  death. death is more often associated with polysubstance use  (especially benzodiazepines  with other  cns depressants such as opioids and alcohol) . dependence: physical dependence clonazepam tablets may produce physical dependence from continued therapy. physical dependence is a state that develops as a result of physiological adaptation in response to repeated drug use, manifested by withdrawal signs and symptoms after abrupt discontinuation or a significant dose reduction of a drug. abrupt discontinuation or rapid dosage reduction of benzodiazepines or administration of flumazenil, a benzodiazepine antagonist, may precipitate acute withdrawal reactions, including seizures, which can be life-threatening. patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or  rapid dosage reduction include those who take higher dosages (i.e., higher and/or more frequent doses) and those who have had longer durations of use (see warnings: dependence and withdrawal reactions) to reduce the risk of withdrawal reactions, use a gradual taper to discontinue clonazepam tablets or reduce the dosage (see dosage and administration: discontinuation or dosage reduction of clonazepam tablets and warnings: dependence and withdrawal reactions). acute withdrawal signs and symptoms acute withdrawal signs and symptoms associated with benzodiazepines have included abnormal involuntary movements, anxiety, blurred vision, depersonalization, depression, derealization, dizziness, fatigue, gastrointestinal adverse reactions (e.g., nausea, vomiting, diarrhea, weight loss, decreased appetite), headache, hyperacusis, hypertension, irritability, insomnia, memory impairment, muscle  pain and stiffness, panic attacks, photophobia, restlessness, tachycardia, and tremor. more severe acute withdrawal signs and symptoms, including life-threatening reactions, have  included catatonia, convulsions, delirium tremens, depression, hallucinations, mania, psychosis, seizures and suicidality. protracted withdrawal syndrome protracted withdrawal syndrome associated with benzodiazepines is characterized by anxiety, cognitive impairment, depression, insomnia, formication, motor symptoms (e.g.,  weakness,  tremor,  muscle twitches), paresthesia, and tinnitus that persists beyond 4 to  6  weeks after initial benzodiazepine withdrawal. protracted withdrawal symptoms may last weeks to more  than 12 months . as  a result, there may be difficulty in differentiating withdrawal symptoms from potential re-emergence or continuation of symptoms for which the benzodiazepine was being used. tolerance tolerance to clonazepam tablets  may  develop  from continued  therapy.  tolerance is a physiological state characterized by a reduced response to  a drug  after repeated administration (i.e., a higher dose of a drug is required to produce the same effect that was once obtained at a lower dose). tolerance to the therapeutic effect of clonazepam tablets may  develop; however, little tolerance develops to the amnestic reactions and other cognitive impairments caused by benzodiazepines. following the short-term treatment of patients with panic disorder in studies 1 and 2 (see clinical pharmacology: clinical trials) , patients were gradually withdrawn during a 7-week downward- titration (discontinuance) period. overall, the discontinuance period was associated with good tolerability and a very modest clinical deterioration, without evidence of a significant rebound phenomenon. however, there are not sufficient data from adequate and well-controlled long-term clonazepam studies in patients with panic disorder to accurately estimate the risks of withdrawal symptoms and dependence that may be associated with such use. what is the most important information i should know about clonazepam tablets? - clonazepam tablet is a benzodiazepine medicine. taking benzodiazepines with opioid medicines, alcohol, or other central nervous system (cns) depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression), coma, and death. get emergency help right away if any of the following happens: - shallow or slowed breathing - breathing stops (which may lead to the heart stopping) - excessive sleepiness (sedation) do not drive or operate heavy machinery until you know how taking clonazepam tablets with opioids affects you. - risk of abuse, misuse, and addiction . there is a risk of abuse, misuse, and addiction with benzodiazepines, including clonazepam tablet which can lead to overdose and serious side effects including coma and death. - serious side effects including coma and death have happened in people who have abused or misused benzodiazepines, including clonazepam tablets. these serious side effects may also include delirium, paranoia, suicidal thoughts or actions, seizures, and difficulty breathing. call your healthcare provider or go to the nearest hospital emergency room right away if you get any of these serious side effects. - you can develop an addiction even if you take clonazepam tablets as prescribed by your healthcare provider. - take clonazepam tablets exactly as your healthcare provider prescribed. - do not share your clonazepam tablets with other people. - keep clonazepam tablets in a safe place and away from children. - physical dependence and withdrawal reactions. clonazepam tablets can cause physical dependence and withdrawal reactions. do not suddenly stop taking clonazepam tablets . stopping clonazepam tablets suddenly can cause serious and life-threatening side effects, including, unusual movements, responses, or expressions, seizures, sudden and severe mental or nervous system changes, depression, seeing or hearing things that others do not see or hear, an extreme increase in activity or talking, losing touch with reality, and suicidal thoughts or actions. call your healthcare provider or go to the nearest hospital emergency room right away if you get any of these symptoms. some people who suddenly stop benzodiazepines have symptoms that can last for several weeks to more than 12 months, including, anxiety, trouble remembering, learning, or concentrating, depression, problems sleeping, feeling like insects are crawling under your skin, weakness, shaking, muscle twitching, burning or prickling feeling in your hands, arms, legs or feet, and ringing in your ears. physical dependence is not the same as drug addiction. your healthcare provider can tell you more about the differences between physical dependence and drug addiction. do not take more clonazepam tablets than prescribed or take clonazepam tablets for longer than prescribed. - do not suddenly stop taking clonazepam tablets . stopping clonazepam tablets suddenly can cause serious and life-threatening side effects, including, unusual movements, responses, or expressions, seizures, sudden and severe mental or nervous system changes, depression, seeing or hearing things that others do not see or hear, an extreme increase in activity or talking, losing touch with reality, and suicidal thoughts or actions. call your healthcare provider or go to the nearest hospital emergency room right away if you get any of these symptoms. - some people who suddenly stop benzodiazepines have symptoms that can last for several weeks to more than 12 months, including, anxiety, trouble remembering, learning, or concentrating, depression, problems sleeping, feeling like insects are crawling under your skin, weakness, shaking, muscle twitching, burning or prickling feeling in your hands, arms, legs or feet, and ringing in your ears. - physical dependence is not the same as drug addiction. your healthcare provider can tell you more about the differences between physical dependence and drug addiction. - do not take more clonazepam tablets than prescribed or take clonazepam tablets for longer than prescribed. - clonazepam tablets can make you sleepy or dizzy and can slow your thinking and motor skills. this may get better over time. do not drive, operate heavy machinery, or do other dangerous activities until you know how clonazepam tablets affects you. clonazepam tablets may cause problems with your coordination, especially when you are walking or picking things up. - do not drive, operate heavy machinery, or do other dangerous activities until you know how clonazepam tablets affects you. - clonazepam tablets may cause problems with your coordination, especially when you are walking or picking things up. - do not drink alcohol or take other drugs that may make you sleepy or dizzy while taking clonazepam tablets until you talk to your healthcare provider. when taken with alcohol or drugs that cause sleepiness or dizziness, clonazepam tablets may make your sleepiness or dizziness worse. - like other antiepileptic drugs, clonazepam tablets may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. call your healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you: - thoughts about suicide or dying ◦ attempt to commit suicide ◦ new or worse depression - new or worse anxiety ◦ feeling agitated or restless ◦ panic attacks - trouble sleeping (insomnia) ◦ new or worse irritability ◦ acting aggressive, being angry, or violent - acting on dangerous impulses ◦ an extreme increase in activity and talking (mania) ◦ other unusual changes in behavior or mood how can i watch for early symptoms of suicidal thoughts and actions? - pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. - keep all follow-up visits with your healthcare provider as scheduled. call your healthcare provider between visits as needed, especially if you are worried about symptoms. suicidal thoughts or actions can be caused by things other than medicines. if you have suicidal thoughts or actions, your healthcare provider may check for other causes. do not stop clonazepam tablets without first talking to a healthcare provider. - stopping clonazepam tablets suddenly can cause serious problems. stopping clonazepam tablets - suddenly can cause seizures that will not stop (status epilepticus). what are clonazepam tablets? - clonazepam tablets are prescription medicine used alone or with other medicines to treat: certain types of seizure disorders (epilepsy) in adults and children panic disorder with or without fear of open spaces (agoraphobia) in adults - certain types of seizure disorders (epilepsy) in adults and children - panic disorder with or without fear of open spaces (agoraphobia) in adults clonazepam tablet is a federally controlled substance (c-iv) because it contains clonazepam that can be abused or lead to dependence. keep clonazepam tablets in a safe place to prevent misuse and abuse. selling or giving away clonazepam tablets may harm others, and is against the law. tell your healthcare provider if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs. it is not known if clonazepam tablets are safe or effective in treating panic disorder in children younger than 18 years old. who should not take clonazepam tablets? do not take clonazepam tablets if you: - are allergic to benzodiazepines - have significant liver disease - have an eye disease called acute narrow angle glaucoma ask your healthcare provider if you are not sure if you have any of the problems listed above. before you take clonazepam tablets, tell your healthcare provider if you: - have liver or kidney problems - have lung problems (respiratory disease) - have or have had depression, mood problems, or suicidal thoughts or behavior - have any other medical problems - are pregnant or plan to become pregnant. it is not known if clonazepam tablets can harm your unborn baby. tell your healthcare provider right away if you become pregnant while taking clonazepam tablets. you and your healthcare provider will decide if you should take clonazepam tablets while you are pregnant. - studies in pregnant animals have shown harmful effects of benzodiazepine medications (including the active ingredient in clonazepam tablets) on the developing fetus. - children born to mothers receiving benzodiazepine medications (including clonazepam tablets) late in pregnancy may be at some risk of experiencing breathing problems, feeding problems, hypothermia, and withdrawal symptoms. - if you become pregnant while taking clonazepam tablets, talk to your healthcare provider about registering with the north american antiepileptic drug pregnancy registry. you can register by calling 1-888-233-2334. the purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy - are breastfeeding or plan to breastfeed. clonazepam can pass into breast milk. you and your healthcare provider should decide how you will feed your baby while you take clonazepam tablets. tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. taking clonazepam tablets with certain other medicines can cause side effects or affect how well clonazepam tablets or the other medicines work. do not start or stop other medicines without talking to your healthcare provider. how should i take clonazepam tablets? - take clonazepam tablets exactly as your healthcare provider tells you. if you take clonazepam tablets for seizures, your healthcare provider may change the dose until you are taking the right amount of medicine to control your symptoms. - clonazepam is available as a tablet. - do not stop taking clonazepam tablets without first talking to your healthcare provider. stopping clonazepam tablets suddenly can cause serious problems. - clonazepam tablets should be taken with water and swallowed whole. - if you take too much clonazepam tablets, call your healthcare provider or local poison control center right away. what should i avoid while taking clonazepam tablets? - clonazepam tablets can slow your thinking and motor skills. do not drive, operate heavy machinery, or do other dangerous activities until you know how clonazepam tablets affects you. - do not drink alcohol or take other medicines that may make you sleepy or dizzy while taking clonazepam tablets until you talk to your healthcare provider. when taken with alcohol or medicines that cause sleepiness or dizziness, clonazepam tablets may make your sleepiness or dizziness much worse. what are the possible side effects of clonazepam tablets? see “what is the most important information i should know about clonazepam tablets?” clonazepam tablets can also make your seizures happen more often or make them worse. call your healthcare provider right away if your seizures get worse while taking clonazepam tablets. the most common side effects of clonazepam tablets include: - drowsiness • dizziness • fatigue - problems with walking and coordination • depression • problems with memory these are not all the possible side effects of clonazepam tablets. call your doctor for medical advice about side effects. you may report side effects to fda at 1-800-fda-1088 or contact advagen pharma ltd, at 866-488-0312. how should i store clonazepam tablets? - store clonazepam tablets at 20°c to 25°c (68°f -77°f) [see usp controlled room temperature]. - keep clonazepam tablets and all medicines out of the reach of children. general information about the safe and effective use of clonazepam tablets. medicines are sometimes prescribed for purposes other than those listed in a medication guide. do not use clonazepam tablets for a condition for which it was not prescribed. do not give clonazepam tablets to other people, even if they have the same symptoms that you have. it may harm them. you can ask your pharmacist or healthcare provider for information about clonazepam tablets that is written for health professionals. for more information, contact advagen pharma ltd, at 866-488-0312. what are the ingredients in clonazepam tablets? active ingredient: clonazepam inactive ingredients: - 0.5 mg tablets contain lactose monohydrate, polyethylene glycol, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, fd & c yellow 6 al lake, d & c yellow 10 al lake - 1 mg tablets contain lactose monohydrate, polyethylene glycol, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, fd & c blue 1 al lake and fd & c blue 2 al lake - 2 mg tablets contain lactose monohydrate, polyethylene glycol, microcrystalline cellulose, croscarmellose sodium and magnesium stearate this medication guide has been approved by the u.s. food and drug administration. repackaged by / distributed by: remedyrepack inc. 625 kolter drive, indiana, pa 15701 (724) 465-8762

Соединенные Штаты - английский - NLM (National Library of Medicine)

seqirus, inc. - influenza a virus a/idaho/07/2018 (h1n1) antigen (mdck cell derived, propiolactone inactivated (unii: z6y9y35soy) (influenza a virus a/idaho/07/2018 (h1n1) hemagglutinin antigen (mdck cell derived, propiolactone inactivated) - unii:cj7119yk1w), influenza a virus a/indiana/08/2018 (h3n2) antigen (mdck cell derived, propiolactone inactivated) (unii: z5eje3ep8t) (influenza a virus a/indiana/08/2018 (h3n2) hemagglutinin antigen (mdck cell derived, propiolactone inactivated) - unii:4t55w47jol), influenza b vir - flucelvax quadrivalent is an inactivated vaccine indicated for active immunization for the prevention of influenza disease caused by influenza virus subtypes a and type b contained in the vaccine. flucelvax quadrivalent is approved for use in persons 4 years of age and older. for children and adolescents 4 through 17 years of age, approval is based on the immune response elicited by flucelvax quadrivalent. data demonstrating a decrease in influenza disease after vaccination of this age group with flucelvax quadrivalent are not available. [see clinical studies (14)] do not administer flucelvax quadrivalent to anyone with a history of severe allergic reaction (e.g. anaphylaxis) to any component of the vaccine [see description (11) ]. pregnancy exposure registry there is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to flucelvax quadrivalent during pregnancy. women who are vaccinated with flucelvax quadrivalent during pregnancy are encouraged to enroll in the registry by calling

Соединенные Штаты - английский - NLM (National Library of Medicine)

accra pac, inc. (dba kik-indiana) - alcohol (unii: 3k9958v90m) (alcohol - unii:3k9958v90m) - antiseptic - to help decrease bact:eriafgerms on the sk!in that could cause disease. for use when soap and water are not available. - recommended for repeated use.

Индия - английский - Central Drugs Standard Control Organization

indiana o. - atropine sulph.,prednisolone - eye dps - 1,0.25;% - 5ml

Индия - английский - Central Drugs Standard Control Organization

indiana o. - e/e dps - 10ml

Индия - английский - Central Drugs Standard Control Organization

indiana o. - ciprofloxacin - eye dps - 0.3%w/v - 10ml