Ирландия - английский - HPRA (Health Products Regulatory Authority)

zoetis ireland limited - clostridium chauvoei whole culture, inactivated - suspension for injection - 0 unknown - clostridium vaccine qi04ab01 clostridium vaccine - bovine, ovine - immunological - inactivated vaccine

Ирландия - английский - HPRA (Health Products Regulatory Authority)

intervet ireland limited - clostridium chauvoei whole culture, clostridium haemolyticum anaculture, clostridium septicum toxoid, clostridium tetani toxoid, clostridium novyi type b anaculture - suspension for injection - unknown - clostridium vaccine - bovine - immunological - inactivated vaccine

Ирландия - английский - HPRA (Health Products Regulatory Authority)

intervet ireland limited - clostridium chauvoei cells and equivalent toxoid of strain 655; clostridium chauvoei cells and equivalent toxoid of strain 656; clostridium chauvoei cells and equivalent toxoid of strain 657; clostridium chauvoei cells and equivalent toxoid of strain 658; clostridium chauvoei cells and equivalent toxoid of strain 1048 - suspension for injection - . - clostridium; clostridium - cattle, sheep - immunological - inactivated vaccine

Новая Зеландия - английский - Ministry for Primary Industries

schering-plough animal health limited - clostridium chauvoei toxoid/cells; clostridium novyi type b toxoid/cells; clostridium perfringens type d toxoid; clostridium tetani toxoid; sodium selenate; clostridium septicum toxoid - clostridium chauvoei toxoid/cells 0 vaccine; clostridium novyi type b toxoid/cells 0 vaccine; clostridium perfringens type d toxoid 0 vaccine; clostridium tetani toxoid 0 vaccine; sodium selenate 6 g/litre; clostridium septicum toxoid 0 vaccine - parenteral nutrient/electrolyte

Соединенные Штаты - английский - NLM (National Library of Medicine)

glaxosmithkline biologicals sa - clostridium tetani toxoid antigen (formaldehyde inactivated) (unii: k3w1n8yp13) (clostridium tetani toxoid antigen (formaldehyde inactivated) - unii:k3w1n8yp13), corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) (unii: irh51qn26h) (corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) - unii:irh51qn26h), bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) (unii: qsn5xo8zsu) (bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) - unii:qsn5xo8zsu), bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) (unii: 8c367iy4ey) (bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) - unii:8c367iy4ey), bordetella pertussis pertactin antigen (formaldehyde inactivated) (unii: i05o535nv6) (bordetella pertussis pertactin antigen (formaldehyde inactivated) - unii:i05o535nv6) - clostridium tetani toxoid antigen (formaldehyde inactivated) 5 [iu] in 0.5 ml - boostrix is indicated for:     •    active booster immunization against tetanus, diphtheria, and pertussis in individuals aged 10 years and older,     •    immunization during the third trimester of pregnancy to prevent pertussis in infants younger than 2 months of age. do not administer boostrix to individuals with a known history of severe allergic reaction (e.g., anaphylaxis) to any component of boostrix or after a previous dose of any tetanus toxoid-, diphtheria toxoid-, or pertussis antigen-containing vaccine [see description (11)] . encephalopathy within 7 days of administration of a previous dose of a pertussis antigen-containing vaccine that is not attributable to another identifiable cause is a contraindication to administration of any pertussis antigen-containing vaccine, including boostrix. pregnancy exposure registry there is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to boostrix during pregnancy. healthcare providers are encouraged to register women by calling 1-888-452-9622 or visiting http://pregnancyregistry.gsk.com/boostrix.html. risk summary all pregnancies have a risk of birth defect, loss, or other adverse outcomes. in the u.s. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. in a randomized, controlled clinical study (nct02377349), in which the non-u.s. formulation of boostrix was administered during the third trimester of pregnancy, there were no identified vaccine-related adverse effects on pregnancy or on the fetus/newborn child (see data) . available data from the pregnancy registry and from spontaneous and postmarketing reports suggest that the rates of major birth defects and miscarriage in women who received boostrix within 28 days prior to conception or during pregnancy are consistent with estimated background rates (see data) . a developmental toxicity study was performed in female rats administered infanrix prior to mating and boostrix during gestation, 0.1 ml at each occasion (a single human dose is 0.5 ml). in a second study, female rats were administered 0.2 ml of boostrix prior to mating and during the gestation and lactation period. in a third study, female new zealand white rabbits were given 0.5 ml (full human dose) of boostrix (non-u.s. formulation) prior to mating and during gestation. these studies revealed no evidence of harm to the fetus due to boostrix (see data). data human data: safety data from a randomized (1:1), controlled clinical study (nct02377349) (341 non-u.s. formulation of boostrix, 346 placebo pregnancy outcomes) in which the non-u.s. formulation of boostrix was administered to pregnant women during the third trimester did not reveal any vaccine-related adverse effects on pregnancy or on the fetus/newborn child. safety data from prospective clinical studies on the use of boostrix during the first and second trimester of pregnancy are not available. an assessment of data from the u.s. pregnancy exposure registry over approximately 17 years (2005-2022) included 1,523 prospective reports of exposure to boostrix within 28 days prior to conception or during pregnancy. among the 256 reports with known pregnancy outcomes, 19 women were exposed to boostrix in the first trimester with no major birth defects reported and 3 spontaneous abortions with no apparent birth defect; 28 women were exposed to boostrix in the second trimester, and 199 women were exposed to boostrix in the third trimester with no major birth defects reported; 10 women were exposed to boostrix at an unknown timing in pregnancy with no major birth defects reported. an assessment of u.s. spontaneous reports and postmarketing data included 810 prospective reports of exposure to boostrix during pregnancy since may 2005 through 31 august 2022. among the 138 reports with known pregnancy outcomes, 17 women were exposed to boostrix in the first trimester with no major birth defects reported and 2 spontaneous abortions with no apparent birth defect; 26 women were exposed to boostrix in the second trimester, and 92 women were exposed to boostrix in the third trimester with no major birth defects reported; 3 women were exposed to boostrix at an unknown timing in pregnancy with no major birth defects reported. animal data: developmental toxicity studies were performed in female rats and new zealand white rabbits. in one study, female rats were administered 0.1 ml of infanrix (a single human dose is 0.5 ml) by intramuscular injection 30 days prior to mating and 0.1 ml of boostrix (a single human dose is 0.5 ml) by intramuscular injection on gestation days 6, 8, 11, and 15. the antigens in infanrix are the same as those in boostrix, but infanrix is formulated with higher quantities of these antigens. in a second study, female rats were administered 0.2 ml of boostrix by intramuscular injection 28 days and 14 days prior to mating, on gestation days 3, 8, 11, and 15, and on lactation day 7. in these studies, no adverse effects on embryo-fetal or pre-weaning development up to postnatal day 25 were observed; there were no fetal malformations or variations observed. in a third study, female new zealand white rabbits were administered 0.5 ml (full human dose) of boostrix (non-u.s. formulation) by intramuscular injection on premating days -28 and -14 and on gestation days 3, 8, 11, 15, and 24. in this study, no adverse effects on embryo-fetal development related to boostrix were observed; postnatal development was not evaluated. risk summary it is not known whether the vaccine components of boostrix are excreted in human milk. data are not available to assess the effect of administration of boostrix on breastfed infants or on milk production/excretion. the developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for boostrix and any potential adverse effects on the breastfed child from boostrix or from the underlying maternal condition. for preventive vaccines, the underlying maternal condition is susceptibility to disease prevented by the vaccine. boostrix is not indicated for use in children aged younger than 10 years. safety and effectiveness of boostrix in this age group have not been established. in the initial-dose clinical trials, 1,104 subjects aged 65 years and older received boostrix; of these subjects, 299 were aged 75 years and older. adverse events following boostrix were similar in frequency to those reported with the comparator td vaccine [see adverse reactions (6.1)] . a revaccination study of boostrix in adults aged 28 to 73 years [see clinical studies (14.4)] did not include sufficient numbers of subjects aged 65 and older to determine whether they respond differently from younger subjects.

Ирландия - английский - HPRA (Health Products Regulatory Authority)

zoetis belgium s.a. - clostridium chauvoei whole culture, inactivated - suspension for injection - . - clostridium; clostridium - cattle, sheep - immunological - inactivated vaccine

Европейский союз - английский - EMA (European Medicines Agency)

ceva santé animale - clostridium perfringens type c, beta1 toxoid / clostridium perfringens, type a, alpha toxoid / clostridium perfringens, type a, beta2 toxoid / escherichia coli, fimbrial adhesin f4ab / escherichia coli, fimbrial adhesin f4ac / escherichia coli, fimbrial adhesin f5 / escherichia coli, fimbrial adhesin f6 - immunologicals for suidae, inactivated bacterial vaccines (including mycoplasma, toxoid and chlamydia) escherichia + clostridium - pigs - for the passive immunisation of progeny by active immunisation of pregnant sows and gilts to reduce:-           clinical signs (severe diarrhoea) and mortality caused by escherichia coli strains expressing the fimbrial adhesins f4ab, f4ac, f5 and f6-           clinical signs (diarrhoea during the first days of life) associated with clostridium perfringens type a expressing alpha and beta 2 toxins-           clinical signs and mortality associated with haemorrhagic and necrotising enteritis caused by clostridium perfringens type c expressing beta1 toxin

Австралия - английский - APVMA (Australian Pesticides and Veterinary Medicines Authority)

intervet australia pty limited - clostridium perfringens type d - killed; clostridium septicum - killed; clostridium chauvoei - killed; clostridium novyi type b - killed; clostridium tetani-killed; leptospira interrogans serovar hardjo; leptospira interrogans serovar pomona; thiomersal - parenteral liquid/solution/suspension - clostridium perfringens type d - killed vaccine active 5.0 iu/ml; clostridium septicum - killed vaccine active 2.5 iu/ml; clostridium chauvoei - killed vaccine-microbial active 0.0 p; clostridium novyi type b - killed vaccine-microbial active 3.5 iu/ml; clostridium tetani-killed vaccine-microbial active 2.5 iu/ml; leptospira interrogans serovar hardjo vaccine-microbial active 0.0 p; leptospira interrogans serovar pomona vaccine-microbial active 0.0 p; thiomersal mercury other 0.13 g/l - immunotherapy - calf | cattle - beef | dairy cattle | beef calf | bovine | breeders | bullocks | bulls | calf - poddy | calf - preweaning | calf - black disease | blackleg | enterotoxaemia (pulpy kidney) | leptospirosis | malignant oedema | tetanus | clostridium perfringens type d | l. hardjo | l. interrogans | l. pomona | l. tarassovi | tetanus vaccination

Австралия - английский - APVMA (Australian Pesticides and Veterinary Medicines Authority)

intervet australia pty limited - clostridium perfringens type d - killed; clostridium septicum - killed; clostridium chauvoei - killed; clostridium novyi type b - killed; clostridium tetani-killed; thiomersal - parenteral liquid/solution/suspension - clostridium perfringens type d - killed vaccine active 0.0 undefined; clostridium septicum - killed vaccine active 0.0 undefined; clostridium chauvoei - killed vaccine-microbial active 0.0 undefined; clostridium novyi type b - killed vaccine-microbial active 0.0 undefined; clostridium tetani-killed vaccine-microbial active 0.0 undefined; thiomersal mercury other 0.13 g/l - immunotherapy - cattle | sheep | beef | bos indicus | bos taurus | bovine | buffalo | bull | bullock | calf | cow | dairy cow | ewe | heifer | h - black disease | blackleg | enterotoxaemia (pulpy kidney) | malignant oedema | tetanus | clostridium perfringens type d | tetanus vaccination

Австралия - английский - APVMA (Australian Pesticides and Veterinary Medicines Authority)

zoetis australia pty ltd - streptococcus equi; thiomersal - misc. vaccines or anti sera - streptococcus equi vaccine-microbial active 0.0 p; thiomersal mercury other 0.1 mg/ml - immunotherapy - horse | colt | donkey | endurance horse | filly | foal | gelding | high performance horses | horses at stud | mare | pacer | pol - strangles | vaccine | equine rotavirus