RAMIPRIL AN 5mg ramipril 5mg tablet blister pack

Страна: Австралия

Язык: английский

Источник: Department of Health (Therapeutic Goods Administration)

Активный ингредиент:

ramipril

Доступна с:

Amneal Pharma Australia Pty Ltd

ИНН (Международная Имя):

Ramipril

Статус Авторизация:

Registered

тонкая брошюра

_Ramipril AN – Consumer Medicine Information _
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_Doc ID: 93.AN.M.2.0 _
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RAMIPRIL AN TABLETS
_Ramipril _
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some
common questions about
Ramipril AN.
It does not contain all the
available information. It does not
take the place of talking to your
doctor or, pharmacist
All medicines have risks and
benefits. Your doctor has
weighed the risks of you taking
Ramipril AN against the benefits
it is expected to have for you.
IF YOU HAVE ANY CONCERNS
ABOUT TAKING THIS MEDICINE,
ASK YOUR DOCTOR OR
PHARMACIST.
KEEP THIS LEAFLET WITH THE
MEDICINE.
You may need to read it again
WHAT RAMIPRIL AN IS
USED FOR
Ramipril AN belongs to a group
of medicines called angiotensin
converting enzyme (ACE)
inhibitors.
Ramipril AN is used to treat:
• high blood pressure
(hypertension)
• some heart conditions such as
heart failure after a heart attack
• kidney problems in some
patients
Ramipril AN is also used to
reduce the risk of cardiovascular
problems and complications in
patients aged 55 years or more
with heart or blood vessel
disease, or diabetes.
HYPERTENSION
Ramipril AN is used to lower
high blood pressure
(hypertension). Everyone has
blood pressure. This pressure
helps get your blood all around
your body. Your blood pressure
may be different at different
times of the day and can be
influenced by how busy or
worried you are. You have
hypertension when your blood
pressure stays higher than is
needed, even when you are
calm and relaxed.
There are usually no symptoms
of hypertension. The only way of
knowing that you have
hypertension is to have your
blood pressure checked on a
regular basis. If high blood
pressure is not treated it can
lead to serious health problems,
including stroke, heart disease
and kidney failure.
HEART FAILURE AFTER A HEART
ATTACK
Ramipril AN may be used after a
heart attack. A heart attack
occurs when one of the major
blood vessels supplying blood to
your heart becomes blocked.
This means that your heart
muscle cannot r

Характеристики продукта

_Ramipril AN tablets Product Information _
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_ Amneal Pharma Australia Pty Ltd _
Doc ID:94.AN.P.4.0
Page 1
RAMIPRIL AN
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_(RAMIPRIL TABLETS) _
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PRODUCT INFORMATION
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NAME OF THE MEDICINE
The name of the medicine is ramipril.
CHEMICAL NAME:
(2S,3aS,6aS)-1-[(S)-2-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]
propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
MOLECULAR FORMULA:
C
23
H
32
N
2
O
5
MOLECULAR WEIGHT:
416.5
CAS REGISTRY NUMBER:
[
_87333-19-5_
]
DESCRIPTION
Ramipril is a white or almost white, crystalline powder. It is
sparingly soluble in water, freely
soluble in methanol.
RAMIPRIL is available as tablets containing 1.25 mg, 2.5 mg, 5 mg & 10
mg of ramipril.
RAMIPRIL AN tablets contains
following inactive ingredients: pregelatinised maize starch,
lactose monohydrate, sodium bicarbonate, croscarmellose sodium and
sodium stearylfumarate.
The 2.5 mg tablet also contains iron oxide yellow. The 5mg tablet also
contains iron oxide
red.
PHARMACOLOGY
MECHANISM OF ACTION
Ramipril is a prodrug which, after absorption from the
gastrointestinal tract, is hydrolysed in the
liver to form the active moiety, ramiprilat. Ramipril and ramiprilat
inhibit angiotensin-converting
enzyme (ACE) which is identical to KININASE II. This converting enzyme
(ACE) is a peptidyl
dipeptidase that catalyses the conversion of angiotensin I to the
vasoconstrictor substance,
angiotensin II. Angiotensin II also stimulates aldosterone secretion
by the adrenal cortex, thus
inhibition of ACE results in decreased plasma angiotensin II, which
leads to decreased vasopressor
activity and to decreased aldosterone secretion. The latter decrease
may result in a
small increase
in serum potassium.
KININASE II is one of the enzymes responsible for the degradation of
bradykinin, a potent
_Ramipril AN tablets Product Information _
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_ Amneal Pharma Australia Pty Ltd _
Doc ID:94.AN.P.4.0
Page 2
vasodepressor
peptide.
The
inhibition
of
KININASE
II
activity
by
ramipril
prevents
the
degradation of bradykinin thus leading to i