QUELICIN SOLUTION

Страна: Канада

Язык: английский

Источник: Health Canada

Активный ингредиент:

SUCCINYLCHOLINE CHLORIDE

Доступна с:

PFIZER CANADA ULC

код АТС:

M03AB01

ИНН (Международная Имя):

SUXAMETHONIUM

дозировка:

20MG

Фармацевтическая форма:

SOLUTION

состав:

SUCCINYLCHOLINE CHLORIDE 20MG

Администрация маршрут:

INTRAVENOUS

Штук в упаковке:

5/10/20ML

Тип рецепта:

Prescription

Терапевтические области:

NEUROMUSCULAR BLOCKING AGENTS

Обзор продуктов:

Active ingredient group (AIG) number: 0105141001; AHFS:

Статус Авторизация:

APPROVED

Дата Авторизация:

2004-04-23

Характеристики продукта

_Prescribing Information - _
_Pr_
_Quelicin _
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_Page 1 of 14 _
PRESCRIBING INFORMATION
Pr
QUELICIN
®
Succinylcholine Chloride Injection USP
20 mg / mL
Sterile Solution
NEUROMUSCULAR BLOCKING AGENT
ATC code: M03AB01
Pfizer Canada ULC
17300 Trans-Canada Highway
Kirkland, Québec
H9J 2M5
Control Number: 280413
DATE OF REVISION:
February 26, 2024
_Prescribing Information - _
_Pr_
_Quelicin _
_ _
_Page 2 of 14 _
PRESCRIBING INFORMATION
PR
QUELICIN
®
Succinylcholine Chloride Injection USP
20 mg / mL
Sterile Solution
Neuromuscular Blocking Agent
ACTION AND CLINICAL PHARMACOLOGY
Succinylcholine is an ultra short-acting, depolarizing-type, skeletal
muscle relaxant. As does acetylcholine,
it combines with the cholinergic receptors of the motor end plate to
produce depolarization. This
depolarization may be observed as fasciculations. Subsequent
neuromuscular transmission is inhibited so
long as adequate concentration of succinylcholine remains at the
receptor site. Onset of flaccid paralysis is
rapid (less than one minute after i.v. administration), and with
single administration lasts approximately 4
to 6 minutes.
Succinylcholine is rapidly hydrolysed by plasma cholinesterase to
succinylmonocholine (which possesses
clinically insignificant depolarizing muscle relaxant properties) and
then more slowly to succinic acid and
choline (see PRECAUTIONS). About 10% of the drug is excreted unchanged
in the urine. The paralysis
following administration of succinylcholine chloride is progressive,
initially involving consecutively the
levator muscles of the face, muscles of the glottis and finally the
intercostals and the diaphragm and all
other skeletal muscles.
Succinylcholine has no direct action on the uterus or other smooth
muscle structures. Because it is highly
ionized and has low fat solubility, it does not readily cross the
placenta.
Tachyphylaxis occurs with repeated administration (see PRECAUTIONS).
Depending on the dose and duration of succinylcholine administration,
the characteristic depolarizing
neuromuscular bloc