Pen-Strep 20/20

Страна: Армения

Язык: английский

Источник: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում

Активный ингредиент:

procaine (procaine benzylpenicillin G), dihydrostreptomycin (dihydrostreptomycin sulfate)

Доступна с:

Norbrook Laboratories

ИНН (Международная Имя):

procaine (procaine benzylpenicillin G), dihydrostreptomycin (dihydrostreptomycin sulfate)

дозировка:

200000IU/ml+200mg/ml

Фармацевтическая форма:

suspension for injection

Тип рецепта:

Prescription

Характеристики продукта

PEN-STREP 20/20
INJECTABLE SUSPENSION
1. NAME
PEN-STREP 20/20
2. COMPOSITION
Benzylpenicillin procaine 200.000 I.U. - Dihydrostreptomycin sulphate
(250 mg) equiv. to
dihdyrostreptomycin 200 mg
EXCIPIENTS: Sodium citrate 10 mg - Sodium methylparahydroxybenzoate
1.14 mg - Povidone 5 mg -
Sodium formaldehyde sulfoxylate 2 mg - Water for injections up to 1
ml.
3. PHARMACEUTICAL FORM
Injectable suspension for intramuscular injection.
4. PHARMACOLOGICAL PROPERTIES
PEN-STREP 20/20 is a combination of the procaine salt of benzyl
penicillin and dihydrostreptomycin
(as sulphate).
* _Pharmacological groups:_ procaine benzyl penicillin is a
beta-lactam antibiotic and
dihydrostreptomycin belongs to the amino glycosides.
* _Mode of action:_
- Benzyl penicillin interferes with the enzymatic development of the
bacterial cell wal of Gram-positive
bacteria. The inability of benzyl penicillin to affect Gram-negative
bacteria can be explained by the
structure of the Gram-negative cell wall: the extra layer in the
Gram-negative cell wall consists of
endotoxin (lipopolysaccharide) with benzyl penicillin cannot
penetrate. Penicillins are bactericidal at
high concentrations (from 0.05 IU/ml), bacteriostatic at low
concentrations. Antibacterial action of
benzyl penicillin is highest during the period of greates bacterial
multiplication (acute infections).
- Dihydrostreptomycin binds specifically to a protein in the bacterial
30S ribosomal subunit. In
susceptible bacteria this binding causes disruption of the ribosomal
subunit and "misreading" of the
information on the messenger RNA. This misreading leads to the
synthesis by the bacterium of what
are called "nonsense" proteins which do not fit anywhere in the
bacterium. Dihydrostreptomycin acts
bactericidal and is most effective against Gram-negative bacteria such
as _Pasteurella, Brucella, _
_Haemophilus, Salmonella, Shigella, Klebsiella _and _Mycobacterium_.
The combination of both antibiotics has a broad-spectrum action
against both Gram-negative and
Gram-positive organisms.
SUMMARY OF