Страна: Великобритания
Язык: английский
Источник: MHRA (Medicines & Healthcare Products Regulatory Agency)
Hypromellose
Blumont Healthcare Ltd
S01XA20
Hypromellose
3mg/1ml
Eye drops
No Controlled Drug Status
Valid as a prescribable product
BNF: 11080100
1601- info v8 Page 1 of 3 HYPROMELLOSE 0.3% W/V EYE DROPS NAME: Hypromellose 0.3% w/v eye drops INTENDED PURPOSE/USE: Lubrication of the eye. Blumont Hypromellose Drops are an ocular lubricant, intended for use as artificial tears. The soothing and lubricating qualities of Hypromellose relieves ocular discomfort and irritation associated with dry eyes and environmental factors such as wind, salt water, smoke or computer work. FORMULATION: Each gram contains Hypromellose 3.0 mg/ml, benzalkonium chloride 0.1 mg/ml, sodium chloride 0.45 mg/ml, potassium chloride 0.37 mg/ml, borax 0.19mg/ml, boric acid 0.19 mg/ml, distilled water q.s. PRODUCT CHARACTERISTICS: Hypromellose (HPMC or Hydroxypropylmethylcellulose) is a substituted cellulose ether that is commonly used in artificial tear formulations. (Pensyl 2001) This colloid dissolves in water to produce a colorless solution of varying viscosity (according to the concentration). It has proper optical clarity, a refractive index similar to cornea, and is nearly inert chemically. Its relative lack of toxicity, its viscous properties, and its beneficial effects on tear film stability have made cellulose ethers such as hypromellose useful components of artificial tear preparations. Hypromellose is not pharmacologically active; it exerts its therapeutic effect by virtue of the physical characteristics of the eye drops acting as an ocular lubricant. After instillation, hypromellose eye drops spreads evenly over the ocular surface and forms a transparent film over the conjunctival and corneal surfaces without any streaks. Hypromellose is slightly less viscous than methylcellulose but possess cohesive and emollient properties equal to or superior to methylcellulose. (Pensyl 2001) Its very good surface properties are considered superior to other methylcellulose preparations. (Marquardt 1992) Studies have also shown that these viscous substances slow the elimination of tear fluid as a result of their high molecular structure and the tendency of such molecules to form networks. A Прочитать полный документ