NORADRENALINE SINTETICA CONCENTRATE FOR SOLUTION FOR INFUSION 1MGML

Страна: Сингапур

Язык: английский

Источник: HSA (Health Sciences Authority)

Активный ингредиент:

Noradrenaline Tartrate eqv Noradrenaline

Доступна с:

INTEVIS PTE LTD

код АТС:

C01CA03

Фармацевтическая форма:

INFUSION, SOLUTION CONCENTRATE

состав:

Noradrenaline Tartrate eqv Noradrenaline 1.000mg/ml

Администрация маршрут:

INTRAVENOUS

Тип рецепта:

Prescription Only

Производитель:

Sintetica SA

Статус Авторизация:

ACTIVE

Дата Авторизация:

2022-10-05

тонкая брошюра

rate and rhythm than in the hypotensive state. In hypotension
that persists after correction of blood volume deficits,
norepinephrine helps raise the blood pressure to an optimal
level and establish a more adequate circulation.
INDICATIONS AND USAGE
For the restoration of blood pressure in certain acute
hypotensive states (e.g., pheochromocytomectomy,
sympathectomy, poliomyelitis, spinal anesthesia, myocardial
infarction, septicemia, blood transfusion, and drug reactions).
As an adjunct in the treatment of cardiac arrest.
To restore and maintain an adequate blood pressure after an
effective heartbeat and ventilation have been established by
other means.
CONTRAINDICATIONS
Noradrenaline Sintetica should not be given to patients
who are hypotensive from blood volume deficits except as
an emergency measure to maintain coronary and cerebral
artery perfusion until blood volume replacement therapy
can be completed. If Noradrenaline Sintetica is continuously
administered to maintain blood pressure in the absence
of blood volume replacement, the following may occur:
severe peripheral and visceral vasoconstriction, decreased
renal perfusion and urine output, poor systemic blood flow
despite “normal” blood pressure, tissue hypoxia, and lactate
acidosis.
Noradrenaline Sintetica should also not be given to patients
with mesenteric or peripheral vascular thrombosis (because
of the risk of increasing ischemia and extending the area of
infarction) unless, in the opinion of the attending physician,
the administration of Noradrenaline Sintetica is necessary as
a life-saving procedure.
Cyclopropane and halothane anesthetics increase cardiac
autonomic irritability and therefore seem to sensitize the
myocardium to the action of intravenously administered
adrenaline or noradrenaline. Hence, the use of Noradrenaline
Sintetica during cyclopropane and halothane anesthesia is
generally considered contraindicated because of the risk of
producing ventricular tachycardia or fibrillation.
The same type of cardiac arrhythmias may result fr

Характеристики продукта

Version – June 2022
Noradrenaline Sintetica 1 mg/ml
Noradrenaline tartrate
Solution for infusion
Rx only
DESCRIPTION
Noradrenaline (sometimes referred to as l-arterenol/Levarterenol or l-
norepinephrine) is a
sympathomimetic amine which differs from adrenaline by the absence of
a methyl group on
the nitrogen atom.
Noradrenaline tartrate is (-)-α-(aminomethyl)-3,4-dihydroxybenzyl
alcohol tartrate (1:1)
(salt) monohydrate and has the following structural formula:
Noradrenaline Sintetica is supplied in sterile aqueous solution (water
for injections) in the
form of the tartrate salt to be administered by intravenous infusion
following dilution.
Noradrenaline is sparingly soluble in water, very slightly soluble in
alcohol and ether, and
readily soluble in acids. Each mL contains the equivalent of 1 mg base
of noradrenaline and
sodium chloride for isotonicity. It has a pH of 3 to 4.5. The air in
the ampoules has been
displaced by nitrogen gas.
CLINICAL PHARMACOLOGY
Noradrenaline, a sympathomimetic amine, acts predominantly on α
receptors and on β
receptors in the heart. It therefore causes peripheral
vasoconstriction (α-adrenergic action),
and a positive inotropic effect on the heart and dilation of coronary
arteries (β-adrenergic
action). These actions result in an increase in systemic blood
pressure and coronary artery
blood flow. In myocardial infarction accompanied by hypotension,
norepinephrine usually
increases aortic blood pressure, coronary artery blood flow, and
myocardial oxygenation,
thereby helping to limit the area of myocardial ischaemia and
infarction. Venous return is
increased and the heart tends to resume a more normal rate and rhythm
than in the
hypotensive state. In hypotension that persists after correction of
blood volume deficits,
norepinephrine helps raise the blood pressure to an optimal level and
establish a more
adequate circulation.
INDICATIONS AND USAGE
For
the
restoration
of
blood
pressure
in
certain
acute
hypotensive
states
(e.g.,
pheochromocytomectomy, sympathectomy, poliomyelitis