Muphoran

Страна: Австралия

Язык: английский

Источник: Department of Health (Therapeutic Goods Administration)

Активный ингредиент:

Fotemustine

Доступна с:

Servier Laboratories (Australia) Pty Ltd

класс:

Medicine Registered

тонкая брошюра

MUPHORAN
®

_fotemustine (pronounced fo-te-mus-teen )_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some of the
common questions about
MUPHORAN. It does not contain all
the available information. Reading
this leaflet does not take the place of
talking to your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you being treated with
MUPHORAN against the expected
benefits for you.
IF YOU HAVE ANY CONCERNS ABOUT
BEING TREATED WITH THIS MEDICINE,
ASK YOUR DOCTOR, PHARMACIST, OR
ONCOLOGY NURSE.
KEEP THIS LEAFLET IN A SAFE PLACE.
You may need to read it again.
WHAT MUPHORAN IS
The name of your medicine is
MUPHORAN. The active ingredient
of MUPHORAN is called
fotemustine. Fotemustine is a type of
chemotherapy that belongs to a group
of anti-cancer agents called
nitrosoureas (pronounced ni-tro-so-u-
ree-as).
WHAT MUPHORAN IS
USED FOR
YOU HAVE BEEN PRESCRIBED
MUPHORAN FOR MELANOMA (ALSO
KNOWN AS MALIGNANT MELANOMA).
MUPHORAN is available only with
a prescription - usually from an
experienced cancer specialist (also
known as an oncologist).
WHY MUPHORAN IS
USED FOR MELANOMA
Melanoma is a type of skin cancer.
Sometimes melanoma spreads from
the skin to the lung, liver, bowel, or
brain.
MUPHORAN works by stopping the
rapid growth of some types of cancer
cells.
MUPHORAN treatment can shrink
and slow the growth of melanoma
tumours for some patients. Other
patients may not have a useful
treatment response from
MUPHORAN.
Ask your doctor if you have any
questions about why you are being
treated with MUPHORAN.
BEFORE YOU ARE TREATED
WITH MUPHORAN
There are some people who shouldn't
be treated with MUPHORAN. Please
read the following lists. If you think
any of these situations apply to you
or you have any questions, please
consult your doctor, pharmacist, or
oncology nurse.
WHEN YOU MUST NOT BE
TREATED WITH
MUPHORAN
•
YOU ARE ALLERGIC TO FOTEMUSTINE
OR ANY OTHER NITROSOUREA.
 Symptoms of an allergic reaction
to MUPHORAN may include
short

Характеристики продукта

MUPHORAN
®
 (FOTEMUSTINE) 
– Product Information 

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_MUPHORAN_
_®_

PRODUCT INFORMATION 

NAME OF THE MEDICINE 

Registered tradename:  _MUPHORAN _

DESCRIPTION 

Chemical name: Diethyl 1-[3-(2-chloroethyl)-3-nitrosureido] ethylphosphonate  RS 

INN (recommended): fotemustine 

Formulae: 

Structural Formula: 

Molecular formula:  

C
9
H
19
CIN
3
O
5
P 

Molecular weight (relative):  315.7 

Physicochemical properties: 

Physical form:  
pale yellow powder 
Solubility: 

results obtained show that fotemustine, in accordance with the  

standards of the European pharmacopoeia is slightly soluble
in  

water and soluble in 95% ethanol 
pH: 

6.3 (03% aqueous solution) 
pKa: 

10.4 for the acid group 
Polymorphism: 
an infrared spectrophotometric study carried out on several batches 
shows no polymorphism 
Partition coefficient:  octanol/water of 15.7-17.9
(pH 2.1- 7.4) 

_ _
PHARMACOLOGY 

Fotemustine

is  a  cytostatic  anticancer  agent  of  the  nitrosourea  family  with  an  alkylating  and 
carbamoylating effect with
a wide spectrum of experimental antitumoral activity. 

PHARMACODYNAMICS 

Fotemustine  is  a  cytostatic  antineoplastic  agent  whose  chemical  formula  includes  a  bioiostere  of 
alanine  (1-amino  ethylphosphonic  acid)  in  order  to  facilitate  cellular  penetration  and  passage 
across the blood-brain barrier. 

In animal pharmacology, its spectrum of anticancer activity is very wide and is exerted on tumours 
of various histological types and
in various anatomical sites, particularly cerebral and visceral. 

MUPHORAN
®
 (FOTEMUSTINE) 
– Product Information 

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