Страна: Малайзия
Язык: английский
Источник: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Warfarin Sodium Clathrate
GoodScience Sdn. Bhd.
Warfarin Sodium Clathrate
100 Tablets
Sriprasit Pharma Co. Ltd.
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ MAFORAN TABLET Warfarin Sodium (as Warfarin Sodium Clathrate) (1 mg, 2 mg, 5 mg) _ _ 1 WHAT IS IN THIS LEAFLET 1. What Maforan is used for 2. How Maforan works 3. Before you use Maforan 4. How to use Maforan 5. While you are using it 6. Side effects 7. Storage and Disposal of Maforan 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT MAFORAN IS USED FOR Maforan is used to prevent and/or to treat blood clots forming in blood vessels. It helps to reduce the tendency of blood to form clots in the legs, lungs, brain or heart, and to prevent formation or reoccurrence of blood clots after heart attack. HOW MAFORAN WORKS Maforan contains warfarin sodium that belongs to a group of medicines called anticoagulants. It increases the times it takes for your blood to clot and prevent excessive clotting. BEFORE YOU USE MAFORAN - _When you must not use it_ Do not use Maforan if you: • are allergic to warfarin sodium, or any ingredients in this medication. • are pregnant or plan for a pregnancy. • have a bleeding tendency or bruise easily. • have any scheduled operations/surgeries, even minor. • have high blood pressure that is not controlled by medicines. • suffer from severe liver insufficiency or liver cirrhosis. • have certain conditions such as: - stomach or intestinal bleeding or ulcers; - bleeding in the lungs or kidneys, bladder or urethra; - cerebral haemorrhage (bleeding in the brain); - heart infection; - swelling of the heart membrane or fluid in the heart; - brain aneurysm (swelling of an artery that supplies blood to the brain). • have tendency to fall due to neurological or other health-related conditions. • have dementia, psychoses, alcoholism or another situation where the anticoagulant treatment cannot be administrated safely. • are taking medicines that may increase your risk of bleeding or other medicines that stop the blood from clotting. • have a physical condition which might have a risk of Прочитать полный документ
COMPOSITION Each MAFORAN 1 MG, 2 MG, 3 MG, 4 MG and 5 MG TABLET contains Warfarin Sodium 1 mg, 2 mg, 3 mg, 4 mg and 5 mg (as Warfarin Sodium Clathrate) respectively. DESCRIPTION MAFORAN 1 MG TABLET: White flat round tablet with a bisect and debossed with “MAFORAN”, “1” on one side, plain on the other. MAFORAN 2 MG TABLET: Orange flat round tablet with a bisect and debossed with “MAFORAN”, “2” on one side, plain on the other. MAFORAN 3 MG TABLET: Dark blue flat round tablet with a bisect and debossed with “MAFORAN”, “3” on one side, plain on the other. MAFORAN 4 MG TABLET: Yellow flat round tablet with a bisect and debossed with “MAFORAN”, “4” on one side, plain on the other. MAFORAN 5 MG TABLET: Pink flat round tablet with a bisect and debossed with “MAFORAN”, “5” on one side, plain on the other. PHARMACODYNAMICS Warfarin or 4-hydroxycoumarin is an anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent clotting factors II, VII, IX and X, and the anticoagulant proteins C and S. Of its isomers, S-warfarin is approximately 5 times as potent an anticoagulant as R-warfarin. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K-dependent clotting factors. Vitamin K promotes the biosynthesis RI Ȗ-carboxyglutamic acid residues in the proteins that are essential for biological activity. Warfarin is thought to interfere with clotting factor synthesis by inhibition of the C1 subunit of vitamin K epoxide reductase (VKORC1) enzyme complex, thereby reducing the regeneration of vitamin K1 epoxide. The degree of depression is dependent upon the dosage administered. Therapeutic doses of warfarin decrease the total amount of the active form of each vitamin K dependent clotting factor made by the liver by approximately 30% to 50%. An anticoagulation effect generally occurs within 24 hours after drug administration. However, peak coagulant effect may be delayed 72 to 96 hours. The duration of action of a single dose of racemic warfarin is 2 Прочитать полный документ