LISINOPRIL tablet

Страна: Соединенные Штаты

Язык: английский

Источник: NLM (National Library of Medicine)

Активный ингредиент:

LISINOPRIL (UNII: E7199S1YWR) (LISINOPRIL ANHYDROUS - UNII:7Q3P4BS2FD)

Доступна с:

TYA Pharmaceuticals

ИНН (Международная Имя):

LISINOPRIL

состав:

LISINOPRIL 5 mg

Администрация маршрут:

ORAL

Тип рецепта:

PRESCRIPTION DRUG

Терапевтические показания :

Lisinopril tablets USP are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including lisinopril. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program’s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC). Numerous antihypertensive drugs, from a variety of pharmacologic classes and with differ

Обзор продуктов:

NDC:64725-5400-1 in a BOTTLE of 100 TABLETS

Статус Авторизация:

Abbreviated New Drug Application

Характеристики продукта

LISINOPRIL- LISINOPRIL TABLET
TYA PHARMACEUTICALS
----------
LISINOPRIL TABLETS USP
WARNING: FETAL TOXICITY
_SEE FULL PRESCRIBING INFORMATION FOR COMPLETE BOXED WARNING._
•
•
DESCRIPTION
Lisinopril is an oral long-acting angiotensin converting enzyme
inhibitor. Lisinopril, a synthetic peptide
derivative, is chemically described as (S)-1-[N2-(1-carboxy-3-
phenylpropyl)-L-lysyl]-L-proline
dihydrate. Its empirical formula is C H N O • 2H O and its
structural formula is:
Lisinopril is a white to off-white, crystalline powder, with a
molecular weight of 441.53. It is soluble
in water and sparingly soluble in methanol and practically insoluble
in ethanol.
Lisinopril tablets USP is supplied as 2.5 mg, 5 mg, 10 mg, 20 mg, 30
mg and 40 mg tablets for oral
administration.
Inactive Ingredients:
2.5 mg tablets – calcium phosphate, magnesium stearate, mannitol,
corn starch.
5 mg, 10 mg and 30 mg tablets – calcium phosphate, magnesium
stearate, mannitol, red iron oxide, corn
starch.
20 mg tablets – calcium phosphate, magnesium stearate, mannitol, red
iron oxide, corn starch, yellow
iron oxide.
40 mg tablets – calcium phosphate, magnesium stearate, mannitol,
corn starch, yellow iron oxide.
CLINICAL PHARMACOLOGY
MECHANISM OF ACTION
Lisinopril inhibits angiotensin-converting enzyme (ACE) in human
subjects and animals. ACE is a
peptidyl dipeptidase that catalyzes the conversion of angiotensin I to
the vasoconstrictor substance,
angiotensin II. Angiotensin II also stimulates aldosterone secretion
by the adrenal cortex. The beneficial
effects of lisinopril in hypertension and heart failure appear to
result primarily from suppression of the
renin-angiotensin-aldosterone system. Inhibition of ACE results in
decreased plasma angiotensin II
WHEN PREGNANCY IS DETECTED, DISCONTINUELISINOPRILAS SOON AS POSSIBLE.
DRUGS THAT ACT DIRECTLY ON THE RENIN-ANGIOTENSIN SYSTEM CAN CAUSE
INJURY AND DEATH TO
THE DEVELOPING FETUS. SEE WARNINGS, FETAL TOXICITY.
2131352
which leads to decreased vasopressor activity and to decreased
aldoster