LIDOCAINE HYDROCHLORIDE injection

Страна: Соединенные Штаты

Язык: английский

Источник: NLM (National Library of Medicine)

Активный ингредиент:

LIDOCAINE HYDROCHLORIDE (UNII: V13007Z41A) (LIDOCAINE - UNII:98PI200987)

Доступна с:

Medical Purchasing Solutions, LLC

ИНН (Международная Имя):

LIDOCAINE HYDROCHLORIDE

состав:

LIDOCAINE HYDROCHLORIDE ANHYDROUS 20 mg in 1 mL

Администрация маршрут:

INTRAVENOUS

Тип рецепта:

PRESCRIPTION DRUG

Терапевтические показания :

Lidocaine hydrochloride administered intravenously, is specifically indicated in the acute management of ventricular arrhythmias such as those occurring in relation to acute myocardial infarction, or during cardiac manipulation, such as cardiac surgery. Lidocaine hydrochloride is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type. Lidocaine hydrochloride should not be used in patients with Stokes-Adams syndrome. Wolff-Parkinson-White syndrome, or with severe degrees of sinoatrial, atrioventricular, or intraventricular block in the absence of an artificial pacemaker. Although specific studies have not been conducted, lidocaine hydrochloride has been used clinically without evidence of abuse of this drug or of physiological or physical dependence as a result of its use.

Обзор продуктов:

Lidocaine Hydrochloride Injection, USP For Direct Intravenous Injection I n unit-use packages containing a Luer-Jet ™ Luer-Lock Prefilled Syringe. Ten cartons per package. Concentration          Stock No.          NDC No.                   Size        2%                     3390           76329-3390-1       5 mL (100 mg) Syringe Assembly Directions: USE ASEPTIC TECHNIQUE Do not assemble until ready to use. *CAUTION: IMPROPER ENGAGING MAY CAUSE GLASS BREAKAGE AND SUBSEQUENT INJURY. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature]. INTERNATIONAL MEDICATION SYSTEMS, LIMITED                 REV. 8-11 So. El Monte , CA 91733, U.S.A. An Amphastar Pharmaceuticals Company

Статус Авторизация:

Abbreviated New Drug Application

Характеристики продукта

LIDOCAINE HYDROCHLORIDE- LIDOCAINE HYDROCHLORIDE INJECTION
MEDICAL PURCHASING SOLUTIONS, LLC
----------
6933900B
LIDOCAINE HYDROCHLORIDE INJECTION, USP {FOR VENTRICULAR ARRYTHMIAS}
RX ONLY
DESCRIPTION
Lidocaine Hydrochloride Injection USP, is a sterile, aqueous solution
of lidocaine, an
antiarrhythmic agent, prepared with the aid of hydrochloric acid. It
is intended for
intravenous administration by either direct injection or continuous
infusion.
Lidocaine hydrochloride is designated 2-(Diethylamino)-2’,
6’-acetoxylidide
monohydrochloride and isrepresented by the following structural
formula:
*pH of the above solution adjusted with sodium hydroxide and/or
hydrochloric acid to
finished product pH limits between 5 and 7.
The medication and fluid pathway of these disposable syringes are
sterile and
nonpyrogenic in the original, unopened package with component caps in
place. These
dosage forms do not contain preservatives; once the unit is assembled
and used, any
remaining portion of the solution must be discarded with the entire
unit.
CLINICAL PHARMACOLOGY
MECHANISMS OF ACTION AND ELECTROPHYSIOLOGY: Studies of the effects of
therapeutic
concentrations of lidocaine on the electrophysiological properties of
mammalian Purkinje
fibers have shown that lidocaine attenuates phase 4 diastolic
depolarization, decreases
automaticity and causes a decrease or no change in excitability and
membrane
responsiveness. Action potential duration and effective refractory
period of Purkinje
fibers are decreased, while the ratio of effective refractory period
to action potential
duration is increased. Action potential duration and effective
refractory period of
ventricular muscle are also decreased. Effective refractory period of
the AV node may
increase, decrease or remain unchanged, and atrial effective
refractory period is
unchanged. Lidocaine raises the ventricular fibrillation threshold. No
significant
interactions between lidocaine and the autonomic nervous system have
been described
and consequently lidocaine has little or no