Страна: Армения
Язык: английский
Источник: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում
lidocaine
Arpimed LLC
N01BB02
lidocaine
50mg/g
ointment
aluminium tube 15g
Prescription
Registered
2020-05-19
SUMMARY PRODUCT CHARACTERISTIC (SPC) LIDOCAINE 5% OINTMENT BRAND NAME – Lidocaine 5% ointment INTERNATIONAL NON-PROPERTY NAME – Lidocaine PHARMACEUTICAL FORM: Ointment GENERAL CHARACTERISTICS _ PHYSICAL AND CHEMICAL PROPERTIES _ White homogeneous odorless ointment. COMPOSITION Each gram contains: _ACTIVE INGREDIENT: _ lidocaine – 50 mg; _ INACTIVE INGREDIENTS:_ polyethylene glycol 400, polyethylene glycol 4000, propylene glycol, water purified. PHARMACOLOGICAL GROUP AND ATC CODE Local anaesthetic; N01BB02. PHARMACOLOGY Lidocaine is a local anesthetic of the amide type with actions. Lidocaine blocks the generation and conduction of impulses through all nerve fibers-sensory, motor, and autonomic. Lidocaine appears to block conduction of nerve impulses bу decreasing permeability of the nerve cell membrane to sodium ions, thereby decreasing the rate of depolarization of the nerve membrane, increasing threshold for electrical excitability, and preventing propagation of the potential. PHARMACOKINETICS _АBSORPTION:_Lidocaine is readily absorbed from mucous membranes. The rate and extent of absorption depends upon concentration and total dose administered, the specific site of application and duration of exposure. Perfusion rate in the mucous membranes influences on the absorption. _DISTRIBUTION: _Lidocaine is widely distributed into highly perfused tissues including kidney, lung, liver, heart, and also penetrates into the adipose tissue. Penetrates into the placenta by passive diffusion. Distribution in the placenta may be sufficient to penetrate into the embryo and achieving toxic levels. Lidocaine rapidly cross the placenta, appearing in the bloodstream of the embryo during several minutes after application by mother. Lidocaine is bound to plasma proteins, including α 1 -acid glycoprotein (AAG). The extent of binding is variable but is about 60-80%. This indicates that the binding with plasma proteins increases in patients with uraemia and renal transplant recipients, and increases after acute myocardial infa Прочитать полный документ