Страна: Великобритания
Язык: английский
Источник: MHRA (Medicines & Healthcare Products Regulatory Agency)
H & R Healthcare Ltd
No Controlled Drug Status
Never Valid To Prescribe As A VMP
BNF:
INTRODUCTION Kendall™ AMD antimicrobial foam dressings incorporate the effective antimicrobial agent POLYHEXAMETHYLENE BIGUANIDE (PHMB — also known as polihexanide) with a highly absorbent foam. These dressings are particularly suited to the management of acute or chronic wounds with moderate to high levels of exudation where there is an increased risk or evidence of wound infection. Authors: Spruce P, Edwards-Jones V, Ivins N, Ciprandi G, Sibbald RG, Shah C, Patel H. Full author details can be found on page 6. ROLE OF ANTIMICROBIAL DRESSINGS All chronic wounds contain a mixture of different bacteria, often from the patient’s skin or intestinal tract. These may include some known pathogens that ultimately cause infection. Common pathogens seen in chronic wounds include Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and occasionally a mixture of anaerobic bacteria and fungi. The bacteria may secrete a range of toxins and enzymes that degrade newly formed tissue and perpetuate an inflammatory reaction. This may cause problems such as delayed wound healing or wound degradation 1 . Furthermore, it is now widely accepted that most chronic wounds contain biofilms 2 . These comprise a thin layer of microorganisms, which are bound in a matrix of secreted polymers that adhere to the wound bed surface 3 . Bacteria growing in a biofilm are up to 1,000 times more resistant to antibiotics than the same bacteria outside a biofilm 4 . As a result, systemic antimicrobial therapy may not be effective. In recent years, the management of increased wound bioburden has moved towards the use of topical antimicrobial agents because of mounting recognition of the problems caused by antibiotic resistance. Unlike antibiotics, which generally have a single mode of action, topical antimicrobial agents tend to have multiple modes of action on microbial cells. This means that they have a broad spectrum of antimicrobial activity and a low risk of developing resistance 5 . Increasingly, topical antimicrobial agents are Прочитать полный документ