HYDROCORTISONE IODOQUINOL- hydrocortisone, iodoquinol cream

Страна: Соединенные Штаты

Язык: английский

Источник: NLM (National Library of Medicine)

Активный ингредиент:

HYDROCORTISONE (UNII: WI4X0X7BPJ) (HYDROCORTISONE - UNII:WI4X0X7BPJ), IODOQUINOL (UNII: 63W7IE88K8) (IODOQUINOL - UNII:63W7IE88K8)

Доступна с:

Seton Pharmaceuticals

Администрация маршрут:

TOPICAL

Тип рецепта:

PRESCRIPTION DRUG

Терапевтические показания :

Based on a review of a related drug by the National Research Council and subsequent FDA classification for that drug, the indications are as follows: "Possibly" Effective: Contact or atopic dermatitis; impetiginized eczema; nummular eczema; endogenous chronic infectious dermatitis; stasis dermatitis; pyoderma; nuchal eczema and chronic eczematoid otitis externa; acne urticata; localized or disseminated neurodermatitis; lichen simplex chronicus; anogenital pruritus (vulvae, scroti, ani); folliculitis; bacterial dermatoses; mycotic dermatoses such as tinea (capitis, cruris, corporis, pedis); moniliasis; intertrigo. Final classification of the less-than-effective indications requires further investigation. This product is contraindicated in persons with known or suspected hypersensitivity to any of the ingredients of the product.

Обзор продуктов:

1 oz. tubes, NDC 13925-175-01 To report a serious adverse event or obtain product information, call 1-855-899-4237. Manufactured for: Seton Pharmaceuticals Manasquan, NJ 08736 1-800-510-3401 v1 Rev. 10/2018

Статус Авторизация:

unapproved drug other

Характеристики продукта

HYDROCORTISONE IODOQUINOL- HYDROCORTISONE, IODOQUINOL CREAM
SETON PHARMACEUTICALS
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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HYDROCORTISONE 1%-IODOQUINOL 1% CREAM
RX ONLY
DESCRIPTION:
Each gram contains 10 mg of hydrocortisone and 10 mg of iodoquinol in
a vehicle consisting of:
ceteareth-6, ceteareth-25, cetyl alcohol, chloroxylenol, citric acid,
glyceryl stearate SE, mineral oil,
propylene glycol, purified water, stearyl alcohol, and xanthan gum.
Paraben Free.
Chemically, hydrocortisone is [Pregn-4-ene-3, 20-dione, 11, 17,
21-trihydroxy-,(11 B)-1 with the
molecular formula (C21 H3005) and is represented by the following
structural formula:
and iodoquinol, 5,7-diiodo-8-quinolinol (C9H5l2NO) is represented by
the following structural
formula:
Hydrocortisone is an anti-inflammatory and antipruritic agent, while
iodoquinol is an antifungal and
antibacterial agent.
CLINICAL PHARMACOLOGY:
Hydrocortisone has anti-inflammatory, antipruritic and
vasoconstrictive properties. While the
mechanism of anti-inflammatory activity is unclear, there is evidence
to suggest that a recognizable
correlation exists between vasoconstrictor potency and therapeutic
efficacy in humans. lodoquinol has
both antifungal and antibacterial properties.
PHARMACOKINETICS :
The extent of percutaneous absorption of topical steroids is
determined by many factors including the
vehicle, the integrity of the epidermal barrier and the use of
occlusive dressings. Hydrocortisone can
be absorbed from normal intact skin. Inflammation and/or other
inflammatory disease processes in the
skin increase percutaneous absorption. Occlusive dressings
substantially increase the percutaneous
absorption of topical corticosteroids. Once absorbed through the skin,
hydrocortisone is metabolized in
the liver and most body tissue to hydrogenated and degraded forms such
as tetrahydrocortisone and
tetrahydrocortisol. These ar