HYDROCORTISONE ACETATE PRAMOXINE HCL

Страна: Соединенные Штаты

Язык: английский

Источник: NLM (National Library of Medicine)

Активный ингредиент:

HYDROCORTISONE ACETATE (UNII: 3X7931PO74) (HYDROCORTISONE - UNII:WI4X0X7BPJ)

Доступна с:

Perrigo New York Inc

ИНН (Международная Имя):

HYDROCORTISONE ACETATE

состав:

HYDROCORTISONE ACETATE 2.5 g in 100 g

Тип рецепта:

PRESCRIPTION DRUG

Статус Авторизация:

unapproved drug other

Характеристики продукта

HYDROCORTISONE ACETATE PRAMOXINE HCL- HYDROCORTISONE ACETATE PRAMOXINE
HCL
PERRIGO NEW YORK INC
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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HYDROCORTISONE ACETATE 2.5% PRAMOXINE HCL 1% CREAM
Emollient Formula
Kit
RX ONLY
DESCRIPTION
HYDROCORTISONE ACETATE 2.5% AND PRAMOXINE HCL 1% CREAM is a topical
preparation containing
hydrocortisone acetate 2.5% w/w and pramoxine hydrochloride 1% w/w in
an emollient formula base
containing cetostearyl alcohol, ceteth 20, light mineral oil, white
petrolatum, propylparaben,
triethanolamine lauryl sulfate, citric acid, sodium citrate, and
purified water.
Topical corticosteroids are anti-inflammatory and anti-pruritic
agents. The structural formula, the
chemical name, molecular formula and molecular weight for the active
ingredients are presented below.
CLINICAL PHARMACOLOGY
Topical corticosteroids share anti-inflammatory, anti-pruritic and
vasoconstrictive actions.
The mechanism of anti-inflammatory activity of topical corticosteroids
is unclear. Various laboratory
methods, including vasoconstrictor assays, are used to compare and
predict potencies and/or clinical
efficacies of the topical corticosteroids. There is some evidence to
suggest that a recognizable
correlation exists between vasoconstrictor potency and therapeutic
efficacy in man.
Pramoxine hydrochloride is a topical anesthetic agent which provides
temporary relief from itching and
pain. It acts by stabilizing the neuronal membrane of nerve endings
with which it comes into contact.
PHARMACOKINETICS
The extent of percutaneous absorption of topical corticosteroids is
determined by many factors
including the vehicle, the integrity of the epidermal barrier, and the
use of occlusive dressings.
Topical corticosteroids can be absorbed from normal intact skin.
Inflammation and/or other disease
processes in the skin increase percutaneous absorption. Occlusive
dressings substan