Страна: Австралия
Язык: английский
Источник: Department of Health (Therapeutic Goods Administration)
Metformin hydrochloride
Aspen Pharma Pty Ltd
Medicine Registered
FORMET ASPEN 500_ 1 FORMET ASPEN 500 CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about FORMET ASPEN 500. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risk of you taking FORMET ASPEN 500 against the benefits it is expected to have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. YOU MAY WANT TO READ IT AGAIN. WHAT FORMET ASPEN 500 IS USED FOR The name of your medicine is FORMET ASPEN 500. It contains the active ingredient metformin hydrochloride. Metformin is used to control blood glucose in patients with diabetes mellitus, when diet and exercise are not enough to control blood glucose. There are two types of diabetes mellitus: Type I, also called insulin dependent diabetes Type II, also called non- insulin dependent diabetes mellitus (NIDDM) or maturity onset diabetes. Metformin can be used in patients with Type I diabetes mellitus where insulin alone is not enough to control blood glucose levels. Metformin can also be used in patients with Type II diabetes mellitus. It can be used alone or in combination with other medicines for treating diabetes. Your doctor may have prescribed FORMET ASPEN 500 tablets for another reason. Ask your doctor if you have any questions about why FORMET ASPEN 500 was prescribed for you. HOW FORMET ASPEN 500 WORKS Metformin belongs to a group of medicines called biguanides. Metformin lowers high blood glucose by helping you Прочитать полный документ
1 FORMET ASPEN 500 TABLETS FORMET ASPEN 500 _Metformin hydrochloride_ PRODUCT INFORMATION LIFE THREATENING LACTIC ACIDOSIS CAN OCCUR DUE TO ACCUMULATION OF METFORMIN. RISK FACTORS INCLUDE RENAL IMPAIRMENT, OLD AGE AND THE USE OF HIGH DOSES OF METFORMIN ABOVE 2 G PER DAY. NAME OF THE MEDICINE Metformin hydrochloride. [http://www.appco.com.au/appguide/drug.asp?drug_id=00202405] The chemical name for metformin hydrochloride is 1, 1-dimethylbiguanide hydrochloride. C 4 H 11 N 5 •HCl Molecular weight: 165.6 Cas No: 1115-70-4 DESCRIPTION Metformin hydrochloride is a white, crystalline powder which is odourless or almost odourless and hygroscopic. It is freely soluble in water, slightly soluble in ethanol (96%), and practically insoluble in chloroform and in ether. Each FORMET ASPEN 500 tablet contains 500 mg of metformin hydrochloride. The tablets also contain the following excipients: sodium starch glycollate type A, povidone, maize starch, magnesium stearate, colloidal anhydrous silica, hypromellose, macrogol 6000, purified talc, titanium dioxide and propylene glycol. The tablets are gluten free. PHARMACOLOGY Metformin is an oral biguanide hypoglycaemic agent. It causes an increased peripheral uptake of glucose by increasing the biological efficiency of available exogenous or endogenous insulin. The mode of action of metformin may be linked to an increase of insulin sensitivity. It does not stimulate insulin release but does require the presence of insulin to exert its hypoglycaemic effect. Possible mechanisms of action include inhibition of gluconeogenesis in the liver, delay in glucose absorption from the gastrointestinal tract and an increase in peripheral uptake of glucose. Прочитать полный документ